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Bruce J. Schnapp
Researcher at Harvard University
Publications - 40
Citations - 8794
Bruce J. Schnapp is an academic researcher from Harvard University. The author has contributed to research in topics: Kinesin & Microtubule. The author has an hindex of 30, co-authored 40 publications receiving 8522 citations. Previous affiliations of Bruce J. Schnapp include Oregon Health & Science University & Boston University.
Papers
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Journal ArticleDOI
Direct observation of kinesin stepping by optical trapping interferometry
TL;DR: It is found that kinesin moves with 8-nm steps, similar to biological motors that move with regular steps.
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Bead movement by single kinesin molecules studied with optical tweezers
TL;DR: The results of this study are consistent with a model in which kinesin detaches briefly from the microtubule during a part of each mechanochemical cycle, rather than a models in whichKinesin remains bound at all times.
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Tracking kinesin-driven movements with nanometre-scale precision
TL;DR: Measurements reveal basic mechanical features of kinesin-driven movements along the micro-tubule lattice, and place significant constraints on possible molecular mechanisms of movement.
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Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.
Kristen J. Verhey,Debra J. Meyer,Reneé Deehan,John Blenis,Bruce J. Schnapp,Tom A. Rapoport,Ben Margolis +6 more
TL;DR: Results demonstrate a direct interaction between conventional kinesin and a cargo, indicate that motor proteins are linked to their membranous cargo via scaffolding proteins, and support a role for motor proteins in spatial regulation of signal transduction pathways.
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Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro
Ronald D. Vale,Bruce J. Schnapp,Timothy J. Mitchison,Eric R. Steuer,Thomas S. Reese,Michael P. Sheetz,Michael P. Sheetz +6 more
TL;DR: Results indicate that there is a retrograde bead translocator which is pharmacologically and immunologically distinct from kinesin, a direction that corresponds to anterograde transport in the axon.