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Bruna Amanda Girardi
Researcher at Universidade Federal de Santa Maria
Publications - 9
Citations - 146
Bruna Amanda Girardi is an academic researcher from Universidade Federal de Santa Maria. The author has contributed to research in topics: Spermidine & Polyamine binding. The author has an hindex of 6, co-authored 9 publications receiving 118 citations.
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Journal ArticleDOI
Piracetam Prevents Scopolamine-Induced Memory Impairment and Decrease of NTPDase, 5′-Nucleotidase and Adenosine Deaminase Activities
Patricia C. Marisco,Fabiano B. Carvalho,Michelle Melgarejo da Rosa,Bruna Amanda Girardi,Jessié Martins Gutierres,Jeandre Augusto dos Santos Jaques,Ana Paula Snovarski Salla,Victor C. Pimentel,Maria Rosa Chitolina Schetinger,Daniela B.R. Leal,Carlos Fernando Mello,Maribel Antonello Rubin +11 more
TL;DR: Piracetam-induced improvement of memory is associated with protection against oxidative stress and maintenance of NTPDase, 5′-nucleotidase and ADA activities, and suggest the purinergic system as a putative target of piracetam.
Journal ArticleDOI
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Fabiano B. Carvalho,Carlos Fernando Mello,Patricia C. Marisco,Raquel Tonello,Bruna Amanda Girardi,Juliano Ferreira,Mauro Schneider Oliveira,Maribel Antonello Rubin +7 more
TL;DR: The results suggest that spermidine-induced decrease of Na(+),K(+)-ATPase activity involves NMDA receptor/NOS/cGMP/PKG pathway.
Journal ArticleDOI
Spermidine improves the persistence of reconsolidated fear memory and neural differentiation in vitro: Involvement of BDNF.
Cristiane Signor,Bruna Amanda Girardi,Arithane Lorena Wendel,Pâmella Karina Santana Frühauf,Micheli M. Pillat,Henning Ulrich,Carlos Fernando Mello,Maribel Antonello Rubin +7 more
TL;DR: Whether the intrahippocampal infusion of spermidine improves the persistence of reconsolidated contextual fear conditioning memory in rats and whether these possible changes depend on BDNF/TrkB signaling in the hippocampus is investigated.
Journal ArticleDOI
Spermidine, a positive modulator of the NMDA receptor, facilitates extinction and prevents the reinstatement of morphine-induced conditioned place preference in mice.
Bruna Amanda Girardi,Shaiana Beck Fabbrin,Arithane Lorena Wendel,Carlos Fernando Mello,Maribel Antonello Rubin +4 more
TL;DR: Findings suggest that SPD facilitated the extinction of morphine-induced CPP by modulating the polyamine binding site of the NMDA receptor, which may be promising for developing novel pharmacological strategies to treat opioid use disorder.
Journal ArticleDOI
Spermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats.
Bruna Amanda Girardi,Daniela Aymone Ribeiro,Cristiane Signor,Michele Muller,Mayara Ana Gais,Carlos Fernando Mello,Maribel Antonello Rubin +6 more
TL;DR: Results suggest that the spermidine-induced enhancement of memory reconsolidation involves PKC activation, and drugs had no effect when they were administered in the absence of reactivation.