C
Carlos Fernando Mello
Researcher at Universidade Federal de Santa Maria
Publications - 152
Citations - 4571
Carlos Fernando Mello is an academic researcher from Universidade Federal de Santa Maria. The author has contributed to research in topics: NMDA receptor & Anticonvulsant. The author has an hindex of 39, co-authored 150 publications receiving 4201 citations. Previous affiliations of Carlos Fernando Mello include University of Kentucky & Universidade Federal do Rio Grande do Sul.
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Effect of Perinatal Lead Exposure on Rat Behaviour in Open-Field and Two-Wky Avoidance Tasks
TL;DR: In this paper, the authors investigated behavior in the open field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats and found that lead exposure associated with behavioural alterations.
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Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice
Fabiane R Souza,Vanessa T Souza,Viviane Ratzlaff,Lysandro P. Borges,Marli R. Oliveira,Helio G. Bonacorso,Nilo Zanatta,Marcos A. P. Martins,Carlos Fernando Mello +8 more
TL;DR: It is suggested that MPCA and PPCA cause antipyresis, which is similar to that caused by dipyrone, and may be useful antipyretic agents.
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Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat
TL;DR: The present findings suggest that EBS acts on post-receptor events, neutralizing free radicals produced by overstimulation of N-methyl-D-aspartate receptors.
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Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy.
C. R. Vargas,Moacir Wajner,L.R Sirtori,L Goulart,M Chiochetta,Daniella de Moura Coelho,Alexandra Latini,Susana Llesuy,Adriane Belló-Klein,Roberto Giugliani,Marion Deon,Carlos Fernando Mello +11 more
TL;DR: It was verified a significant increase of plasma chemiluminescence and TBA-RS, reflecting induction of lipid peroxidation, as well as a decrease of plasma TAR, indicating a deficient capacity to rapidly handle an increase of reactive species.
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Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures
Mauro Schneider Oliveira,Ana Flávia Furian,Ana Flávia Furian,Luiz Fernando Freire Royes,Michele Rechia Fighera,Natália Gindri Fiorenza,Marcelo Castelli,Pablo Machado,Denise Bohrer,Marlei Veiga,Juliano Ferreira,Esper Abraão Cavalheiro,Carlos Fernando Mello +12 more
TL;DR: Strong converging pharmacological evidence is shown supporting a facilitatory role for the COX-2/PGE(2) pathway in the seizures induced by PTZ, and whether selective COx-2 inhibitors are safer anti-inflammatory drugs for epileptic patients than nonspecific inhibitors remains to be determined.