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Bruna B. Brandão
Researcher at Harvard University
Publications - 16
Citations - 626
Bruna B. Brandão is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Insulin receptor. The author has an hindex of 5, co-authored 11 publications receiving 256 citations. Previous affiliations of Bruna B. Brandão include Federal University of São Paulo & Chestnut Hill College.
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Journal ArticleDOI
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
TL;DR: The findings that led to these conclusions are reviewed and how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease.
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Shortcuts to a functional adipose tissue: The role of small non-coding RNAs.
TL;DR: The fundamental role of small non-coding RNAs (sncRNAs) in these processes are reviewed, with focus on microRNAs, and their importance in adipose tissue function and whole body metabolic control in mammals is demonstrated.
Journal ArticleDOI
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice
Felipe C.G. Reis,Jessica L. O. Branquinho,Bruna B. Brandão,Beatriz Alves Guerra,Ismael Dale Cotrim Guerreiro da Silva,Andrea Frontini,Thomas Thomou,Loris Sartini,Saverio Cinti,C. Ronald Kahn,William T. Festuccia,Alicia J. Kowaltowski,Marcelo A. Mori +12 more
TL;DR: A DR-modulated role for WAT Dicer in controlling metabolism and insulin resistance is evidences, which is accompanied by structural and functional changes in mitochondria, particularly under DR.
Journal ArticleDOI
Extracellular miRNAs as mediators of obesity-associated disease.
TL;DR: The role of extracellular miRNAs in the pathophysiology of obesity and their potential use as biomarkers and in therapy of obesity-associated metabolic syndrome was discussed in this article.
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Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
Mengyao Ella Li,Hans P.M.M. Lauritzen,Brian T. O’Neill,Brian T. O’Neill,Chih-Hao Wang,Weikang Cai,Bruna B. Brandão,Masaji Sakaguchi,Rongya Tao,Michael F. Hirshman,Samir Softic,Samir Softic,C. Ronald Kahn +12 more
TL;DR: It is shown that p110a is the predominant PI3K subunit in muscle, and that its ablation in Muscle, but not ablation of p110beta, leads to insulin resistance, increased proteosomal and autophagic activity, and altered mitochondria homeostasis in mice.