J
Jean-Charles Schwartz
Researcher at French Institute of Health and Medical Research
Publications - 256
Citations - 16341
Jean-Charles Schwartz is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Histamine & Histamine H3 receptor. The author has an hindex of 69, co-authored 252 publications receiving 15917 citations. Previous affiliations of Jean-Charles Schwartz include University of Rouen.
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Journal ArticleDOI
Alternative splicing directs the expression of two D2 dopamine receptor isoforms
Bruno Giros,Pierre Sokoloff,Marie-Pascale Martres,Jean-François Riou,Laurent Emorine,Jean-Charles Schwartz +5 more
TL;DR: It is shown that the gene for the D2 receptor produces two receptor isoforms by alternative messenger RNA splicing, providing a route to receptor diversity in this family of receptors.
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Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.
Maria Pilla,Sylvie Perachon,Sylvie Perachon,F. Sautel,Fabrice Garrido,André Mann,Camille G. Wermuth,Jean-Charles Schwartz,Barry J. Everitt,Pierre Sokoloff +9 more
TL;DR: BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli.
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BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization.
Olivier Guillin,Jorge Diaz,Patrick Carroll,Nathalie Griffon,Jean-Charles Schwartz,Pierre Sokoloff +5 more
TL;DR: It is shown that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens both during development and in adulthood, and may be an important determinant of pathophysiological conditions such as drug addiction, schizophrenia or Parkinson's disease.
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Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
Pierre Sokoloff,Marc Andrieux,Roger Besançon,C. Pilon,Marie-Pascale Martres,Bruno Giros,Jean-Charles Schwartz +6 more
TL;DR: Several agonists and antagonists, previously regarded as autoreceptor-selective, displayed higher affinities at D3 than at D2 receptors, suggesting that they realize differential dopamine receptor subtype occupancy during treatments and that this might be reflected in their clinical profile.
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Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase.
TL;DR: Three types of well defined peptidase activities in CNS may account for the hydrolysis of the opioid pentapeptides : aminopeptidases, angiotensin-converting enzyme and enkephalin-dipeptidylcarboxypeptidase.