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Bryce L. Sopher
Researcher at University of Washington
Publications - 66
Citations - 6873
Bryce L. Sopher is an academic researcher from University of Washington. The author has contributed to research in topics: Neurodegeneration & Ataxin 7. The author has an hindex of 38, co-authored 66 publications receiving 6463 citations. Previous affiliations of Bryce L. Sopher include University of Washington Medical Center & Michigan State University.
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Journal ArticleDOI
The Werner syndrome protein is a DNA helicase.
Matthew D. Gray,Jiang Cheng Shen,Ashwini S. Kamath-Loeb,A. Blank,Bryce L. Sopher,George M. Martin,Junko Oshima,Lawrence A. Loeb +7 more
TL;DR: It is reported that the Werner syndrome protein does indeed catalyze DNA unwinding and is homologous to members of the RecQ family of DNA helicases.
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Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals
Qing Guo,Bryce L. Sopher,Katsutoshi Furukawa,Dao G. Pham,Nic Robinson,George M. Martin,Mark P. Mattson +6 more
TL;DR: In this article, the authors showed that expression of the human presenilin-1 L286V mutation in PC12 cells increases their susceptibility to apoptosis induced by trophic factor withdrawal and Abeta.
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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Qing Guo,Weiming Fu,Bryce L. Sopher,Miles W. Miller,Carol B. Ware,George M. Martin,Mark P. Mattson +6 more
TL;DR: A direct link between a genetic defect that causes AD and excitotoxic neuronal degeneration is established, and new avenues for therapeutic intervention in AD patients are indicated.
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Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Ruiben Feng,Ruiben Feng,Claire Rampon,Ya-Ping Tang,David Shrom,Janice Jin,Maureen Kyin,Bryce L. Sopher,George M. Martin,Seong Hun Kim,Ronald B. Langdon,Sangram S. Sisodia,Joe Z. Tsien +12 more
TL;DR: It is postulated that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories.
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Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain
Katsutoshi Furukawa,Bryce L. Sopher,Russell E. Rydel,James G. Begley,Dao G. Pham,George M. Martin,Michael A. Fox,Mark P. Mattson +7 more
TL;DR: Findings indicate that alternative processing of βAPP has profound effects on the bioactivity of the resultant sAPP products and suggest that reduced levels of sAPPα could contribute to neuronal degeneration in Alzhiemer's disease.