W
Weiming Fu
Researcher at Southern Medical University
Publications - 69
Citations - 7225
Weiming Fu is an academic researcher from Southern Medical University. The author has contributed to research in topics: Wnt signaling pathway & microRNA. The author has an hindex of 37, co-authored 64 publications receiving 6574 citations. Previous affiliations of Weiming Fu include National Institutes of Health & The Chinese University of Hong Kong.
Papers
More filters
Journal ArticleDOI
Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
TL;DR: It is concluded that, by inducing production of Mn‐SOD and suppressing peroxynitrite formation and membrane lipid peroxidation, NF‐κB plays an anti‐apoptotic role in neurodegenerative conditions that involve oxidative stress.
Journal ArticleDOI
The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer
Wei-Cheng Liang,Weiming Fu,Cheuk Wa Wong,Yan Wang,Wei Mao Wang,Guo Xin Hu,Li Zhang,Li Jia Xiao,David Chi Cheong Wan,Jinfang Zhang,Mary M.Y. Waye +10 more
TL;DR: It is implied that the lncRNA H19 modulated the expression of multiple genes involved in EMT by acting as a competing endogenous RNA, which may build up the missing link between the regulatory miRNA network and EMT progression.
Journal ArticleDOI
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Qing Guo,Weiming Fu,Bryce L. Sopher,Miles W. Miller,Carol B. Ware,George M. Martin,Mark P. Mattson +6 more
TL;DR: A direct link between a genetic defect that causes AD and excitotoxic neuronal degeneration is established, and new avenues for therapeutic intervention in AD patients are indicated.
Journal ArticleDOI
The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis.
TL;DR: The data suggest that ER stress plays a role in neuronal cell death induced by an array of insults and that GRP78 serves a neuroprotective function.
Journal ArticleDOI
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.
Ward A. Pedersen,Weiming Fu,Jeffrey N. Keller,William R. Markesbery,Stanley H. Appel,R. Glenn Smith,Edward J. Kasarskis,Mark P. Mattson +7 more
TL;DR: Increased modification of proteins by 4‐hydroxynoneal (HNE), a product of membrane lipid peroxidation, in the lumbar spinal cord of sporadic amyotrophic lateral sclerosis patients versus that of neurologically normal controls is reported.