C. D. Allis

TL;DR: The hypothesis that silencing in yeast results from heterochromatin formation is fortified and it is argued that the silencing proteins participate in this formation.

TL;DR: These data show remarkable preference for lysine 11/12 by the Drosophila HAT B activity in vitro and provide support for the assertion that this activity functions to acetylate new H4, at least in part, for deposition and chromatin assembly in vivo.

TL;DR: The results strongly suggest that the developmentally regulated proteolysis of core histones and dephosphorylation of histone H1 participate in a novel pathway leading to the formation of highly condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development.

TL;DR: Surprisingly, a linker histone found exclusively in transcriptionally inactive micronuclei also has several HMG-like characteristics, including the ability to be specifically extracted from nuclei by elutive intercalation and the presence of the HMG 1 box, which suggests that at least in T. thermophila, proteins with H MG-like properties are not restricted to regions of transcriptionally active chromatin.

TL;DR: It is demonstrated for the first time that an abundant high-mobility-group (HMG)-like protein, HMG B, previously thought to be specific to macron nuclei in Tetrahymena thermophila, is also present in micronuclei, and supports a model wherein H MG B functions to wrap DNA, presumably modulating higher-order chromatin structure for a broad range of biological processes, including transcription and replication.