C E Foley

TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.

TL;DR: Genetically encoded GTP sensors are constructed by inserting a circularly permuted yellow fluorescent protein into a region of the bacterial G protein FeoB that undergoes a GTP-driven conformational change, thereby providing an internally normalized response to changes in GTP levels while minimally perturbing those levels.

TL;DR: It is reported for the first time that depletion of MITF results in elevation of intracellular GTP levels and increased amounts of active (GTP-bound) RAC1, R HO-A and RHO-C, and that the partial repression of GMPR accounts mostly for the above phenotypes in MITF-depleted cells.

TL;DR: It is demonstrated that angustmycin A, a nucleoside-analog inhibitor of GMPS produced by Streptomyces hygroscopius efficiently suppresses melanoma cell invasion in vitro and tumorigenicity in immunocompromised mice.

TL;DR: In this paper , the authors showed that the phosphorylation of Guanosine Monophosphate Reductase (GMPR) at Tyr267 is critical for its activity and found that this activation by ephrin receptor tyrosine kinase EPHA4 decreases GTP pools in cell protrusions and levels of GTP-bound RAC1.