D
Dominic J. Smiraglia
Researcher at Roswell Park Cancer Institute
Publications - 86
Citations - 6372
Dominic J. Smiraglia is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: DNA methylation & Restriction landmark genomic scanning. The author has an hindex of 38, co-authored 82 publications receiving 5797 citations. Previous affiliations of Dominic J. Smiraglia include Ohio State University.
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Journal ArticleDOI
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello,Joseph F. Costello,Michael C. Frühwald,Michael C. Frühwald,Dominic J. Smiraglia,Laura J. Rush,Gavin P. Robertson,Xin Gao,Fred A. Wright,Jamison D. Feramisco,Päivi Peltomäki,James C. Lang,David E. Schuller,Li Yu,Clara D. Bloomfield,Michael A. Caligiuri,Allan J. Yates,Ryo Nishikawa,H.-J. Su Huang,Nicholas J. Petrelli,Xueli Zhang,M. S. O'Dorisio,William A. Held,Webster K. Cavenee,Webster K. Cavenee,Christoph Plass +25 more
TL;DR: This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
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IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data.
Dan Wang,Li Yan,Qiang Hu,Lara Sucheston,Michael J. Higgins,Christine B. Ambrosone,Candace S. Johnson,Dominic J. Smiraglia,Song Liu +8 more
TL;DR: The Illumina Methylation Analyzer (IMA) is a computational package designed to automate the pipeline for exploratory analysis and summarization of site-level and region-level methylation changes in epigenetic studies utilizing the 450K DNA methylation microarray.
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SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
Hui Li,Lois Myeroff,Dominic J. Smiraglia,Michael F. Romero,Theresa P. Pretlow,Lakshmi Kasturi,James Lutterbaugh,Ronald M. Rerko,Graham Casey,Jean Pierre J. Issa,Joseph Willis,James K V Willson,Christoph Plass,Sanford D. Markowitz,Sanford D. Markowitz +14 more
TL;DR: Structural homology and functional testing demonstrated that SLC5A8 is a member of the family of sodium solute symporters, which is now added as a class of candidate colon cancer suppressor genes.
Journal ArticleDOI
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
Dominic J. Smiraglia,Laura J. Rush,Michael C. Frühwald,Michael C. Frühwald,Zunyan Dai,William A. Held,Joseph F. Costello,James C. Lang,Charis Eng,Bin Li,Fred A. Wright,Michael A. Caligiuri,Christoph Plass +12 more
TL;DR: Data indicate that most CpG island hypermethylation observed in cancer cell lines is due to an intrinsic property of cell lines as opposed to the malignant tissue from which they originated.
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Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells.
TL;DR: The studies better define the developmental timing of genome-wide DNA methylation pattern acquisition during male germ cell development and find that both de novo methylation and demethylation occur during spermatogenesis, mainly in s permatogonia and sperMatocytes in early meiotic prophase I.