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C. Jeffery Woodbury
Researcher at University of Wyoming
Publications - 22
Citations - 2341
C. Jeffery Woodbury is an academic researcher from University of Wyoming. The author has contributed to research in topics: Nociceptor & Spinal cord. The author has an hindex of 17, co-authored 22 publications receiving 2061 citations. Previous affiliations of C. Jeffery Woodbury include University of Pittsburgh.
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Journal ArticleDOI
The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Lishi Li,Michael Rutlin,Victoria E. Abraira,Colleen Cassidy,Laura Kus,Shiaoching Gong,Michael P. Jankowski,Wenqin Luo,Nathaniel Heintz,H. Richard Koerber,C. Jeffery Woodbury,David D. Ginty +11 more
TL;DR: It is found that each of the three major hair follicle types of trunk hairy skin (guard, awl/auchene, and zigzag hairs) is innervated by a unique and invariant combination of LTMRs; thus, each hair follicles type is a functionally distinct mechanosensory end organ.
Journal ArticleDOI
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
Rebecca P. Seal,Xingmei Wang,Yabo Guan,Srinivasa N. Raja,C. Jeffery Woodbury,Allan I. Basbaum,Robert H. Edwards +6 more
TL;DR: It is reported that a small subset of cells in the DRG expresses the low abundance vesicular glutamate transporter VGLUT3 (also known as SLC17A8), which impairs mechanical pain sensation and the mechanical hypersensitivity to normally innocuous stimuli that accompanies inflammation, nerve injury and trauma.
Journal ArticleDOI
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses.
C. Jeffery Woodbury,Melissa Zwick,Melissa Zwick,Shuying Wang,Jeffrey J. Lawson,Michael J. Caterina,Martin Koltzenburg,Kathryn M. Albers,H. Richard Koerber,Brian M. Davis +9 more
TL;DR: Vanilloid receptor 1 (TRPV1) has been proposed to be the principal heat-responsive channel for nociceptive neurons but, unlike rat, mouse IB4-positive cutaneous afferents did not express TRPV2 immunoreactivity, and was not required for detecting noxious heat.
Journal ArticleDOI
TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat.
Jeffrey J. Lawson,Sabrina L. McIlwrath,C. Jeffery Woodbury,Brian M. Davis,H. Richard Koerber +4 more
TL;DR: The results suggest that TRPV1 may be essential for heat transduction in a specific subset of mechanically insensitive cutaneous nociceptors and that this subset may constitute a discrete heat input pathway for inflammation-induced thermal pain.
Journal ArticleDOI
The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs
Michael Rutlin,Cheng-Ying Ho,Victoria E. Abraira,Victoria E. Abraira,Colleen Cassidy,Ling Bai,Ling Bai,C. Jeffery Woodbury,David D. Ginty,David D. Ginty +9 more
TL;DR: It is shown that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral direction, which underlies direction-selective responsiveness of A δ- LTMRs to hair deflection.