C
C. Leelayuwat
Researcher at Khon Kaen University
Publications - 48
Citations - 1305
C. Leelayuwat is an academic researcher from Khon Kaen University. The author has contributed to research in topics: Haplotype & Human leukocyte antigen. The author has an hindex of 19, co-authored 42 publications receiving 1260 citations. Previous affiliations of C. Leelayuwat include King Khalid University & University of Western Australia.
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Journal ArticleDOI
Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease
Roger L. Dawkins,C. Leelayuwat,C. Leelayuwat,Silvana Gaudieri,Silvana Gaudieri,Guan K. Tay,Jennie Hui,S.K. Cattley,Patricia Martinez,Jerzy K. Kulski +9 more
TL;DR: A model of the evolution of the human MHC is proposed and explanations for co‐occurrence of genomic polymorphism, duplication and HERVs are considered and it is asked how these features encode susceptibility to numerous and very diverse diseases.
Journal ArticleDOI
A new polymorphic and multicopy MHC gene family related to nonmammalian class I
C. Leelayuwat,David C. Townend,Mariapia A. Degli-Esposti,Lawrence J. Abraham,Roger L. Dawkins +4 more
TL;DR: Genomic sequence analysis of PERB11 from five MHC ancestral haplotypes (AH) indicated that the gene is polymorphic at both DNA and protein level, suggesting a novel polymorphic gene family with multiple copies within the MHC.
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New Major Histocompatibility Complex Genes
Brendan Marshall,C. Leelayuwat,Mariapia A. Degli-Esposti,M. Pinelli,Lawrence J. Abraham,Roger L. Dawkins +5 more
TL;DR: The MHC is a region of some 4 megabases that has been studied intensively owing to the large number of diseases that are associated with susceptibility genes within this region of the genome, but more can be predicted.
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Diversity of MICA (PERB11.1) and HLA haplotypes in Northeastern Thais
Arunrat Romphruk,Taeko Naruse,Amornrat Romphruk,H. Kawata,C. Puapairoj,Jerzy K. Kulski,C. Leelayuwat,Hidetoshi Inoko +7 more
TL;DR: In the present study, polymorphic exons 2, 3 and 4 of the MICA gene were analyzed using sequencing based typing (SBT) in 255 unrelated healthy northeastern Thais to provide the important basis for future analyses on the potential role of theMICA gene in disease susceptibility and transplantation matching in Southeast Asian populations.
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Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais
Charoen Choonhakarn,Amornrat Romphruk,C. Puapairoj,Kunya Jirarattanapochai,Arunrat Romphruk,C. Leelayuwat +5 more
TL;DR: The distributions of the human leukocyte antigen (HLA) at class I and II loci that may contribute to the genetic susceptibility to psoriasis patients in the north‐eastern Thai population are evaluated.