C
C.N. Sridhar
Researcher at University of California, San Diego
Publications - 7
Citations - 1728
C.N. Sridhar is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Prodrug & Cationic liposome. The author has an hindex of 7, co-authored 7 publications receiving 1693 citations.
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Journal ArticleDOI
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations
Jiin Felgner,Raj Kumar,C.N. Sridhar,Carl J. Wheeler,Y. J. Tsai,Border Richard C,P. Ramsey,M. Martin,Philip L. Felgner +8 more
TL;DR: The studies reported here examine the effects of some systematic chemical structural changes in both the cationic lipid components and the neutral phospholipid requirements for transfection activity in COS.
Journal ArticleDOI
Acyclovir diphosphate dimyristoylglycerol : a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus
Karl Y. Hostetler,S Parker,C.N. Sridhar,M J Martin,J L Li,L. M. Stuhmiller,G. M. T. Van Wijk,H. van den Bosch,Michael Gardner,Kathy A. Aldern +9 more
TL;DR: Acyclovir diphosphate diacylglycerol prodrugs may be useful in treating TK-deficient mutant and wild-type strains of HSV, especially in patients with AIDS and other immunosuppressed states.
Journal ArticleDOI
Antiviral activity of phosphatidyl-dideoxycytidine in hepatitis B-infected cells and enhanced hepatic uptake in mice.
Karl Y. Hostetler,Karl Y. Hostetler,Brent E. Korba,C.N. Sridhar,Michael Gardner,Michael Gardner +5 more
TL;DR: DOP-ddC is synthesized, a phospholipid prodrug of ddC which forms lipid bilayers and is readily incorporated into liposomes and may readily be applied to other antiviral nucleosides for HBV.
Journal ArticleDOI
Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice.
Karl Y. Hostetler,Douglas D. Richman,C.N. Sridhar,Philip L. Felgner,J Felgner,J Ricci,Michael F. Gardner,D W Selleseth,M N Ellis +8 more
TL;DR: DOP-ddC, DPP-AZT, and lipid conjugates of other antiretroviral nucleosides may provide higher levels of drug over time in plasma and in lymph nodes and spleen, important reservoirs of HIV infection, and may represent an interesting alternative approach to antiviralucleoside treatment of AIDS.
Journal ArticleDOI
Structural requirements for cationic lipid mediated phosphorothioate oligonucleotides delivery to cells in culture.
C F Bennett,D Mirejovsky,R M Crooke,Y. J. Tsai,Jiin Felgner,C.N. Sridhar,Carl J. Wheeler,Philip L. Felgner +7 more
TL;DR: It is demonstrated that several cationic lipid species enhance the activity of phosphorothioate antisense oligonucleotides and further information is provided on the mechanism by which cATIONic lipids enhance theActivity of phosphorsense oligodeoxynucleotide.