C
C. René Leemans
Researcher at VU University Medical Center
Publications - 233
Citations - 14786
C. René Leemans is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Cancer & Head and neck cancer. The author has an hindex of 59, co-authored 195 publications receiving 12152 citations. Previous affiliations of C. René Leemans include Vanderbilt University Medical Center & University of Florence.
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Journal ArticleDOI
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Hugo J.W.L. Aerts,Emmanuel Rios Velazquez,Ralph T.H. Leijenaar,Chintan Parmar,Patrick Grossmann,Sara Carvalho,Sara Cavalho,Johan Bussink,René Monshouwer,Benjamin Haibe-Kains,Derek H. F. Rietveld,Frank J. P. Hoebers,Michelle M. Rietbergen,C. René Leemans,Andre Dekker,John Quackenbush,Robert J. Gillies,Philippe Lambin +17 more
TL;DR: The data suggest that radiomics identifies a general prognostic phenotype existing in both lung and head-and-neck cancer, which may have a clinical impact as imaging is routinely used in clinical practice, providing an unprecedented opportunity to improve decision-support in cancer treatment at low cost.
Journal ArticleDOI
The molecular landscape of head and neck cancer
TL;DR: It became apparent that HNSCC is a disease characterized by frequent mutations that create neoantigens, indicating that immunotherapies might be effective and that immunotherapy trials with immune checkpoint inhibitors were published, and these may be considered as a paradigm shift in head and neck oncology.
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A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.
Serge J. Smeets,Albertus T. Hesselink,Ernst-Jan M. Speel,Annick Haesevoets,Peter J.F. Snijders,Michael Pawlita,Chris J.L.M. Meijer,Boudewijn J.M. Braakhuis,C. René Leemans,Ruud H. Brakenhoff +9 more
TL;DR: It is shown that clinically meaningful viral HPV infections can be more reliably measured in FFPE H NSCC samples in a standard and high throughput manner, paving the way for prognostic and experimental vaccination studies, regarding not only HNSCC, but possibly also cancer types with HPV involvement in subgroups such as penile and anal cancer.
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Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study
Miranda E.M.C. Christianen,C. Schilstra,Ivo Beetz,Christina T. Muijs,O. Chouvalova,Fred R. Burlage,Patricia Doornaert,Phil W. Koken,C. René Leemans,Rico N. P. M. Rinkel,Marieke J. de Bruijn,G. H. de Bock,Jan L. N. Roodenburg,Bernard F. A. M. van der Laan,Ben J. Slotman,Irma M. Verdonck-de Leeuw,Hendrik P. Bijl,Johannes A. Langendijk +17 more
TL;DR: Physician-rated and patient-rated RISD in head and neck cancer patients treated with (CH) RT cannot be predicted with univariate relationships between the dose distribution in a single organ at risk and an endpoint.
Journal ArticleDOI
Multiple head and neck tumors frequently originate from a single preneoplastic lesion.
Maarten P. Tabor,Ruud H. Brakenhoff,Henrique J. Ruijter-Schippers,Jacqueline E. van der Wal,G. B. Snow,C. René Leemans,Boudewijn J.M. Braakhuis +6 more
TL;DR: Whether first and second primary tumors are clonally related and originate from a single genetically altered field is determined and a proportion of multiple primary tumors have developed within a single preneoplastic field.