C
C. Russell Middaugh
Researcher at University of Kansas
Publications - 297
Citations - 12886
C. Russell Middaugh is an academic researcher from University of Kansas. The author has contributed to research in topics: Circular dichroism & Protein structure. The author has an hindex of 54, co-authored 293 publications receiving 11726 citations.
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Journal ArticleDOI
Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality
John F. Carpenter,Theodore W. Randolph,Wim Jiskoot,Daan J.A. Crommelin,C. Russell Middaugh,Gerhard Winter,Ying-Xin Fan,Susan L. Kirshner,Daniela Verthelyi,Steven Kozlowski,Kathleen A. Clouse,Patrick G. Swann,Amy S. Rosenberg,Barry Cherney +13 more
TL;DR: The purpose of this commentary is to provide brief summaries on the factors affecting protein aggregation and the key aspects of protein aggregation that are associated with immunogenicity, and emphasize the current scientific gaps in understanding and analytical limitations for quantitation of species of large protein aggregates that are referred to as subvisible particles.
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Nanotechnology in vaccine delivery.
TL;DR: Clinical trial results for various vaccine adjuvants and delivery vehicles being developed that are approximately nanoscale (<1000 nm) in size are discussed.
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Barriers to nonviral gene delivery.
TL;DR: The use of various synthetic lipids and polymers to deliver DNA for gene therapy applications and various formulation variables that have been explored to overcome these delivery barriers to nonviral gene delivery are outlined.
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Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development
TL;DR: Key mechanisms of protein-excipient interactions such as electrostatic and cation-pi interactions, preferential hydration, dispersive forces, and hydrogen bonding are presented in the context of different physical states of the formulation.
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Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies.
Ozan S. Kumru,Sangeeta B. Joshi,Dawn E. Smith,C. Russell Middaugh,Ted Prusik,David B. Volkin +5 more
TL;DR: Key concepts in understanding the causes and mechanisms of vaccine instability are covered including the complex and delicate nature of antigen structures, as well as formulation approaches for stabilization within the vaccine cold chain.