C. S. Brian Chia

TL;DR: Solid-state NMR and CD spectroscopy was used to study the effect of antimicrobial peptides from Australian tree frogs on phospholipid membranes, finding an alpha-helical conformation with helix long axis approximately 50 degrees to the bilayer surface at high peptide concentrations.

TL;DR: The feasibility of target mechanism-based whole-cell screening methods, validates ClpP1P2 as a druggable target, and identifies a drug in clinical use as a new lead compound for tuberculosis therapy is demonstrated.

TL;DR: The dorsal glands of Australian tree frogs from the Litoria species contain a diversity of antibiotic peptides that forms part of the defence system of the animal and it is concluded that the kink is important for full biological activity of the peptide, probably because it allows maximum amphipathicity ofThe peptide to facilitate interaction with the membrane.

TL;DR: The data suggest that a P2-arginine shifts the specificity toward DENV2 protease while WNV protease favors a lysine in the P2 position, which generally encourages the investigation of di- and tripeptide aldehydes as inhibitors of DENV and W NV protease.

TL;DR: Nineteen citropin peptides are present in the secretion from the granular dorsal glands of the Blue Mountains tree-frog Litoria citropa; 15 of them are wide-spectrum antibacterial peptides; their role in the amphibian skin is not known.