scispace - formally typeset
Search or ask a question

Showing papers by "C. Shad Thaxton published in 2022"

Journal Article•DOI•
Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platform.

[...]

Dilip Kumar Agarwal1, Somdeep Chatterjee1, Vikas Nandwana1, Stephen E. Henrich1, Vara Prasad V.N. Josyula2, C. Shad Thaxton1, Chao Qi1, Lacy M Simons1, Judd F. Hultquist1, Egon A. Ozer1, Gajendra S. Shekhawat1, Vinayak P. Dravid1 •
Northwestern University1, Cleveland Clinic Lerner Research Institute2
01 Jan 2022-Biosensors and Bioelectronics
TL;DR: In this paper, a microcantilever-based optical detection of SARS-CoV-2 antigenic proteins in just few minutes with high specificity by employing fluidic-atomic force microscopy (f-AFM) mediated nanomechanical deflection method.

24 citations

Journal Article•DOI•
Synthetic Lipid Nanoparticles Actively Target Acute Myeloid Leukemia (AML) Cells and Induce Ferroptosis through Decreased Expression of Glutathione Peroxidase 4

[...]

Adam Yuh Lin, Jonathan S. Rink, Eva Yang, Sara Small, Fransheska Serrano, Yasmin Abaza, Jessica K. Altman, Leonidas C. Platanias, C. Shad Thaxton, Leo I. Gordon 
15 Nov 2022-Blood
TL;DR: In this paper , a synthetic lipid nanoparticle (Au-LNP) that actively targets scavenger receptor type B-1 (SR-B1) was used to target AML cells.
Journal Article•DOI•
Investigations of Redox Resistance in Aggressive Lymphomas with Cholesterol Modulating Lipid Nanoparticles

[...]

Meiying Yang, Jonathan S. Rink, Shuo Yang, Eva Yang, Kaylin M. McMahon, C. Shad Thaxton, Leo I. Gordon, Adam Yuh Lin 
15 Nov 2022-Blood
TL;DR: Rink et al. as mentioned in this paper showed that gold core lipid nanoparticles (Au-LNPs) antagonize lipid uptake through the cell surface receptor called scavenger receptor type B-1 (SR-B1) and lead to cholesterol depletion in several lymphoma cell lines.
Journal Article•DOI•
Receptor Targeted Delivery of the p38γ Inhibitor PIK-75 By Organic-Core Templated Lipid Nanoparticles in Cutaneous T Cell Lymphoma

[...]

Jonathan S. Rink, Stephen E. Henrich, Alexandra Moxley, Xu Hannah Zhang, Xiwei Wu, SonBinh T. Nguyen, Christiane Querfeld, David J. Horne, Steve Rozen, Leo I. Gordon, C. Shad Thaxton, Adam Yuh Lin 
15 Nov 2022-Blood
TL;DR: In this paper , a suite of organic core molecules were synthesized and tested for their ability to support the synthesis of PIK-75 loaded ocLNPs, which are an ideal construct for the delivery of hydrophobic drugs to malignant cells.