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Xiwei Wu
Researcher at City of Hope National Medical Center
Publications - 231
Citations - 13652
Xiwei Wu is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 49, co-authored 191 publications receiving 10647 citations. Previous affiliations of Xiwei Wu include Beckman Research Institute.
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Journal ArticleDOI
Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis
Weiying Zhou,Weiying Zhou,Miranda Y. Fong,Yongfen Min,G. Somlo,Liang Liu,Liang Liu,Melanie R. Palomares,Yang Yu,Yang Yu,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Andrew R. Chin,Yun Yen,Yafan Wang,Eric G. Marcusson,Peiguo Chu,Jun Wu,Xiwei Wu,Arthur X. Li,Zhuo Li,Hanlin Gao,Xiubao Ren,Mark Boldin,Pengnian Charles Lin,Shizhen Emily Wang +25 more
TL;DR: It is shown that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1.
Journal ArticleDOI
Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong,Weiying Zhou,Liang Liu,Aileen Y. Alontaga,Manasa Chandra,Jonathan Ashby,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Shasha Li,Andrew R. Chin,George Somlo,Melanie R. Palomares,Zhuo Li,Jacob R. Tremblay,Akihiro Tsuyada,Guoqiang Sun,Michael A. Reid,Xiwei Wu,Piotr Swiderski,Xiubao Ren,Yanhong Shi,Mei Kong,Wenwan Zhong,Yuan Chen,Shizhen Emily Wang +24 more
TL;DR: It is demonstrated that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
Journal ArticleDOI
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
Xiaoling Wang,Yebo Wang,Xiwei Wu,Jinhui Wang,Yingjia Wang,Zhaojun Qiu,Tammy Chang,He Huang,Ren-Jang Lin,Jiing-Kuan Yee +9 more
TL;DR: The utility of CRISPR-Cas9 and TALENs for genome editing may be compromised by their off-target activity, and it is shown that integrase-defective lentiviral vectors can detect such off- target cleavage with a frequency as low as 1%.
Journal ArticleDOI
Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis
Maria A. Hahn,Runxiang Qiu,Xiwei Wu,Arthur X. Li,Heying Zhang,Jun Wang,Jonathan Jui,Seung-Gi Jin,Yong Jiang,Gerd P. Pfeifer,Qiang Lu +10 more
TL;DR: Analysis of patterns of 5mC and 5hmC during neurogenesis in the embryonic mouse brain suggests that formation of 5HMC and loss of H3K27me3 cooperate to promote brain development, suggesting that5hmC is a stable epigenetic mark.
Journal ArticleDOI
Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally
Huilin Huang,Huilin Huang,Hengyou Weng,Hengyou Weng,Ke-Ren Zhou,Tong Wu,Boxuan Simen Zhao,Mingli Sun,Mingli Sun,Zhenhua Chen,Xiaolan Deng,Xiaolan Deng,Xiaolan Deng,Gang Xiao,Franziska Auer,Lars Klemm,Huizhe Wu,Huizhe Wu,Huizhe Wu,Zhixiang Zuo,Zhixiang Zuo,Xi Qin,Xi Qin,Yunzhu Dong,Yile Zhou,Hanjun Qin,Shu Tao,Juan Du,Jun Liu,Zhike Lu,Hang Yin,Ana Mesquita,Celvie L. Yuan,Yueh-Chiang Hu,Wen-Ju Sun,Rui Su,Rui Su,Lei Dong,Lei Dong,Chao Shen,Chao Shen,Chenying Li,Chenying Li,Ying Qing,Ying Qing,Xi Jiang,Xiwei Wu,Miao Sun,Miao Sun,Jun-Lin Guan,Liang-Hu Qu,Minjie Wei,Markus Müschen,Gang Huang,Chuan He,Jian-Hua Yang,Jianjun Chen,Jianjun Chen +57 more
TL;DR: It is reported that histone H3 trimethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m6A deposition globally, and it is shown that m 6A modifications are enriched in the vicinity of H3K 36me3 peaks, and are reduced globally when cellular H 3K36 me3 is depleted.