C. Shad Thaxton

TL;DR: Prostate specific antigen velocity more than 2 ng/ml per year has been linked to a significantly greater risk of prostate cancer specific mortality, suggesting that screen detected prostate cancer may be more likely to be cured with definitive therapy.

TL;DR: Results are consistent with the hypothesis that inhibition of intraislet NF-&kgr;B activation ameliorates the detrimental effects of host cytokines and demonstrates that preconditioning freshly isolated islets in culture with IKK&bgr; SNA-NCs may be a promising therapy to enhance islet graft function and survival after transplantation.

TL;DR: In this paper, a form of off-target effect DISE (for death induced by survival gene elimination) was proposed for cancer cells in the absence of the target by targeting the 3′UTRs of critical survival genes through canonical RNAi.

TL;DR: The discontinuous lipid milieu supports partial lipidation of apolipoprotein A-I, different from an ordinary phospholipid bilayer, suggesting that synergy between nanoparticle templates and bound phospholIPid layers can modulate amphiphilic proteins for desired functions.

TL;DR: In this paper, the use of nanoparticles having a core and a lipid based shell with optimal lipids therein is described, which are used for treating sepsis using HDL-NP.