C
C.-Thomas Bock
Researcher at Robert Koch Institute
Publications - 19
Citations - 513
C.-Thomas Bock is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: Hepatitis B virus & HBsAg. The author has an hindex of 12, co-authored 19 publications receiving 400 citations.
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Journal ArticleDOI
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.
Daniel Todt,A. Gisa,Aleksandar Radonić,Andreas Nitsche,Patrick Behrendt,Pothakamuri Venkata Suneetha,Sven Pischke,Birgit Bremer,Richard J. C. Brown,Michael P. Manns,Markus Cornberg,C.-Thomas Bock,Eike Steinmann,Heiner Wedemeyer +13 more
TL;DR: This first investigation of intrahost HEV population evolution indicates that RBV causes HEV mutagenesis in treated patients and that an emergence of distinct mutants within the viral population occurs during RBV therapy.
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Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation.
Ingmar Mederacke,Natalie Filmann,Cihan Yurdaydin,Birgit Bremer,Florian Puls,Behrend J. Zacher,Benjamin Heidrich,Hans L. Tillmann,Jens Rosenau,C.-Thomas Bock,Berna Savaş,Fabian A. Helfritz,Frank Lehner,Christian P. Strassburg,Juergen Klempnauer,Karsten Wursthorn,Ulrich Lehmann,Michael P. Manns,Eva Herrmann,Heiner Wedemeyer +19 more
TL;DR: HDV RNA and HBsAg decline follow almost identical kinetic patterns within the first days after LTX, which has to be considered when exploring novel concepts to withdraw HBIG.
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Hepatitis E Virus Mutations: Functional and Clinical Relevance
Hoang Van Tong,Nghiem Xuan Hoan,Bo Wang,Heiner Wedemeyer,C.-Thomas Bock,Thirumalaisamy P. Velavan +5 more
TL;DR: This review aims to compile knowledge and discuss recent advances on the casual role of HEV heterogeneity and its variants on viral morphogenesis, pathogenesis, clinical outcome and antiviral resistance.
Journal ArticleDOI
Molecular epidemiology of hepatitis D virus circulating in Southwestern Nigeria
OO Opaleye,Oluwatoyin Margaret Japhet,O. M. Adewumi,Ewean Chukwuma Omoruyi,Olusola Anuoluwapo Akanbi,Adeolu Sunday Oluremi,Bo Wang,Hoang Van Tong,Thirumalaisamy P. Velavan,C.-Thomas Bock +9 more
TL;DR: A high prevalence of HDV infection in HBsAg carriers and the predominance ofHDV genotype 1 infection in Nigerian HBV endemic region is showed.
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Molecular Epidemiology and Genotyping of Hepatitis B Virus of HBsAg-Positive Patients in Oman
Said Al Baqlani,Bui Tien Sy,Bui Tien Sy,Boris A. Ratsch,Khalid Al Naamani,Salah T. Al Awaidy,Suleiman Salim Al Busaidy,Georg Pauli,C.-Thomas Bock +8 more
TL;DR: The distribution of HBV genotypes, therapy resistance, and vaccine escape mutations in HBV-infected patients in Oman is shown, which will have a major impact on therapy management and diagnostics of chronic HBV infections in Oman.