C
C. Virginia Lockatell
Researcher at University of Maryland, Baltimore
Publications - 24
Citations - 2276
C. Virginia Lockatell is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Proteus mirabilis & Escherichia coli. The author has an hindex of 22, co-authored 24 publications receiving 2148 citations. Previous affiliations of C. Virginia Lockatell include United States Department of Veterans Affairs & Anschutz Medical Campus.
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Journal ArticleDOI
Transcriptome of uropathogenic Escherichia coli during urinary tract infection.
Jennifer A. Snyder,Brian J. Haugen,Eric L. Buckles,C. Virginia Lockatell,David E. Johnson,David E. Johnson,Michael S. Donnenberg,Rodney A. Welch,Harry L. T. Mobley +8 more
TL;DR: This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis.
Journal ArticleDOI
Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection.
Nathan Shankar,C. Virginia Lockatell,Arto S. Baghdayan,Cinthia B. Drachenberg,Michael S. Gilmore,David E. Johnson,David E. Johnson +6 more
TL;DR: Enterococcus faecalis bacteria isolated from patients with bacteremia, endocarditis, and urinary tract infections more frequently express the surface protein Esp than do fecal isolates, and it contributes to colonization and persistence of E. Faecalis at this site.
Journal ArticleDOI
Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold
Laurel S. Burall,Janette M. Harro,Xin Li,C. Virginia Lockatell,Stephanie D. Himpsl,J. Richard Hebel,David E. Johnson,Harry L. T. Mobley +7 more
TL;DR: Isolation of disrupted genes encoding proteins with homologies to known bacterial virulence factors, especially the urease accessory protein UreF and the disulfide formation protein DsbA, showed that the CBA mouse model and mutant pools are a reliable source of attenuated mutants with mutations in virulence genes.
Journal ArticleDOI
Coordinate expression of fimbriae in uropathogenic Escherichia coli.
Jennifer A. Snyder,Brian J. Haugen,C. Virginia Lockatell,Nathalie M. Maroncle,Erin C. Hagan,David E. Johnson,Rodney A. Welch,Harry L. T. Mobley +7 more
TL;DR: Comparison of results with previous studies suggests that inversely coordinated expression of adhesin gene clusters does occur in vivo, and represents evidence for direct communication between genes relating to pathogenesis.
Journal ArticleDOI
Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection.
Susan R. Heimer,David A. Rasko,C. Virginia Lockatell,David E. Johnson,David E. Johnson,Harry L. T. Mobley +5 more
TL;DR: Two chromosomal open reading frames are identified in uropathogenic Escherichia coli (UPEC) strain CFT073 which are highly homologous to serine protease autotransporters Pic and Tsh and were correlated with the presence of 105- to 110-kDa proteins in the culture supernatants.