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C. Wayne Smith
Researcher at Baylor College of Medicine
Publications - 174
Citations - 13957
C. Wayne Smith is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Inflammation & Integrin. The author has an hindex of 56, co-authored 174 publications receiving 13256 citations. Previous affiliations of C. Wayne Smith include University of Virginia & Agricultural Research Service.
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Relationship to impaired redistribution of surface adhesion sites by chemotactic factor or colchicine
TL;DR: In this paper, the mechanism of diminished, stimulated, and directed migration of neonatal polymorphonuclear leukocytes (PMN), chemotactic factor (CF) sensory and PMN effector functions were studied in healthy N and adult or maternal controls (C).
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Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia.
TL;DR: It is concluded that Kupffer cells are mainly responsible for the initial injury, and neutrophils are the dominant cytotoxic cell type during the later phase, and Reactive oxygen generated by both cell types is critical for this pathogenesis.
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A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release
Travis H. Wyman,A. Jason Bjornsen,David J. Elzi,C. Wayne Smith,Kelly M. England,Marguerite R. Kelher,Christopher C. Silliman,Christopher C. Silliman +7 more
TL;DR: Lysophosphatidylcholines (lyso-PCs), generated during blood storage, are etiologic in a two-insult, sepsis-based model of transfusion-related acute lung injury (TRALI).
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ICAM-1 expression in adipose tissue : effects of diet-induced obesity in mice
Danett K. Brake,E. O'Brian Smith,Harry J. Mersmann,C. Wayne Smith,Rebecca L. Robker,Rebecca L. Robker +5 more
TL;DR: Results indicate that within 3 wk on a high-fat diet, male mice exhibited significant increases in pro-inflammatory factors and immune cell infiltration in adipose tissue that may represent links between obesity and its associated inflammatory complications.
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Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
TL;DR: Maternal MD supplementation increases offspring colitis susceptibility that associates with persistent epigenetic and prolonged microbiomic changes, and underscores that epigenomic reprogramming relevant to mammalian colitis can occur during early development in response to maternal dietary modifications.