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Callum J O'Kane
Researcher at Queen's University Belfast
Publications - 5
Citations - 174
Callum J O'Kane is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Epigenetics & Histone. The author has an hindex of 4, co-authored 5 publications receiving 114 citations. Previous affiliations of Callum J O'Kane include Queen's University.
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Journal ArticleDOI
Aspergillus penicillioides differentiation and cell division at 0.585 water activity.
Andrew Stevenson,Philip G Hamill,Callum J O'Kane,Gerhard Kminek,John D. Rummel,Mary A. Voytek,Jan Dijksterhuis,John E. Hallsworth +7 more
TL;DR: This study focused on germination of Aspergillus penicillioides, a xerophile which is also able to grow under low humidity and saline conditions and has an application in understanding the limits to life in extraterrestrial environments.
Journal ArticleDOI
NaCl-saturated brines are thermodynamically moderate, rather than extreme, microbial habitats.
Callum J D Lee,Phillip E McMullan,Callum J O'Kane,Andrew Stevenson,Inês C. Santos,Chayan Roy,Wriddhiman Ghosh,Rocco L. Mancinelli,Melanie R. Mormile,Geoffrey McMullan,Horia L. Banciu,Mario A. Fares,Mario A. Fares,Mario A. Fares,Kathleen C. Benison,Aharon Oren,Michael L. Dyall-Smith,John E. Hallsworth +17 more
TL;DR: The evidence is surveyed that NaCl-saturated brines are biologically permissive, fertile habitats that are thermodynamically mid-range rather than extreme and may be that the finite solubility of NaCl has stabilised the genetic composition of halophile populations and limited the action of natural selection in driving halophile evolution towards greater xerophilicity.
Journal ArticleDOI
Yeast epigenetics: the inheritance of histone modification states.
Callum J O'Kane,Edel M. Hyland +1 more
TL;DR: The recent advancements that for the first time provide a mechanistic understanding of how heterochromatin, dictated by histone modifications specifically, is preserved during S-phase are discussed.
Journal ArticleDOI
Chromatin Structure and Drug Resistance in Candida spp.
TL;DR: The mechanisms by which anti-chromatin therapy, specifically lysine deacetylase inhibitors, influence the acquisition and phenotypic expression of AFR in Candida spp.
Journal ArticleDOI
Probing the role of histone modifications in the evolution of pathogenicity in Candida glabrata
TL;DR: Together, the data suggest that histone PTMs play a significant, and overlapping, role in dictating virulence in C. glabrata, and detail the global transcriptomic response to fluconazole.