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Candice C. Askwith
Researcher at Ohio State University
Publications - 53
Citations - 8026
Candice C. Askwith is an academic researcher from Ohio State University. The author has contributed to research in topics: Acid-sensing ion channel & Cilium. The author has an hindex of 34, co-authored 53 publications receiving 7402 citations. Previous affiliations of Candice C. Askwith include Roy J. and Lucille A. Carver College of Medicine & The Ohio State University Wexner Medical Center.
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Journal ArticleDOI
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.
Chris D. Vulpe,Yien-Ming Kuo,T. L. Murphy,L. Cowley,Candice C. Askwith,Natasha Libina,Jane Gitschier,Gregory J. Anderson +7 more
TL;DR: It is suggested that the hephaestin protein is a multi–copper ferroxidase necessary for iron egress from intestinal enterocytes into the circulation and that it is an important link between copper and iron metabolism in mammals.
Journal ArticleDOI
The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
Candice C. Askwith,David J. Eide,Anthony Van Ho,Philip S. Bernard,Liangtao Li,Sandra Davis-Kaplan,David M. Sipe,Jerry Kaplan +7 more
TL;DR: It is suggested that the catalytic activity of the Fet3 protein is required for cellular iron accumulation, similar to that of the blue multicopper oxidoreductases.
Journal ArticleDOI
Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport
Andrew Dancis,Daniel S. Yuan,David J. Haile,Candice C. Askwith,David J. Eide,Charles Moehle,Jerry Kaplan,Richard D. Klausner +7 more
TL;DR: The identification and characterization of CTR1, a gene in the yeast S. cerevisiae that encodes a multispanning plasma membrane protein specifically required for high affinity copper transport into the cell, provides an unexpected mechanistic link between the uptake of copper and iron.
Journal ArticleDOI
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
John A. Wemmie,Jianguo Chen,Jianguo Chen,Candice C. Askwith,Candice C. Askwith,Alesia Hruska-Hageman,Alesia Hruska-Hageman,Margaret P. Price,Brian C. Nolan,Patrick G. Yoder,Ejvis Lamani,Toshinori Hoshi,Toshinori Hoshi,John H. Freeman,Michael J. Welsh,Michael J. Welsh +15 more
TL;DR: It is found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons, and null mice displayed defective spatial learning and eyeblink conditioning.
Journal ArticleDOI
Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.
TL;DR: It is reported that the proteins disrupted in the human ciliary disorder Bardet–Biedl syndrome are required for the localization of G protein-coupled receptors to primary cilia on central neurons.