Cara Lunn Shirai

TL;DR: In this paper, the authors examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxycycline-inducible transgenic mouse model.

TL;DR: It is found that haematopoietic cells expressing mutant U2AF1(S34F), including primary patient cells, have an increased sensitivity to in vitro sudemycin treatment relative to controls, suggesting a potential for treating haem atological cancers harbouring U2 AF1 mutations with pre-mRNA splicing modulators like sudemies.

TL;DR: Ruxolitinib was an effective salvage therapy for relapsed/refractory secondary hemophagocytic lymphohistiocytosis and the need for intensive chemotherapy or allogeneic transplant in secondary HLH was eliminated.

TL;DR: Findings indicate that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS.

TL;DR: This review focuses on the use of NGS-based MRD detection in AML, including basic methodologies and clinical applications.