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Borja Saez
Researcher at Harvard University
Publications - 56
Citations - 3675
Borja Saez is an academic researcher from Harvard University. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 23, co-authored 51 publications receiving 3067 citations. Previous affiliations of Borja Saez include University of Navarra & Chartered Institute of Management Accountants.
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Journal ArticleDOI
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Sushma Gurumurthy,Stephanie Z. Xie,Brinda Alagesan,Judith Kim,Rushdia Z. Yusuf,Borja Saez,Alexandros Tzatsos,Fatih Ozsolak,Patrice M. Milos,Francesco Ferrari,Peter J. Park,Orian S. Shirihai,David T. Scadden,Nabeel Bardeesy +13 more
TL;DR: A central role is defined for Lkb1 in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in haematopoietic cells through a novel metabolic checkpoint.
Journal ArticleDOI
Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function
Francesca Ferraro,Stefania Lymperi,Simón Méndez-Ferrer,Borja Saez,Joel A. Spencer,Joel A. Spencer,Beow Y. Yeap,Elena Masselli,Gallia Graiani,Lucia Prezioso,Elisa Lodi Rizzini,Marcellina Mangoni,Vittorio Rizzoli,Stephen M. Sykes,Charles P. Lin,Paul S. Frenette,Federico Quaini,David T. Scadden +17 more
TL;DR: The authors suggest that AMD3100 could be used to boost HSC mobilization in diabetic patients who require a bone marrow transplant and suggest that HSPCs were aberrantly localized in the marrow niche of the diabetic mice, and abnormalities in the number of sympathetic nerve termini were associated with this mislocalization.
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AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
Stephen M. Sykes,Steven W. Lane,Lars Bullinger,Demetrios Kalaitzidis,Rushdia Z. Yusuf,Borja Saez,Francesca Ferraro,Francois Mercier,Harshabad Singh,Kristina Brumme,Sanket S. Acharya,Claudia Scholl,Zuzana Tothova,Eyal C. Attar,Stefan Fröhling,Ronald A. DePinho,D. Gary Gilliland,Scott A. Armstrong,David T. Scadden +18 more
TL;DR: In this article, the authors show a converse role for AKT/FOXOs in acute myeloid leukemia (AML) and demonstrate that AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors.
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SIRT1 Regulates Differentiation of Mesenchymal Stem Cells by Deacetylating β-Catenin
Petra Simic,Kayvan Zainabadi,Eric L. Bell,David B. Sykes,Borja Saez,Sutada Lotinun,Roland Baron,David T. Scadden,Ernestina Schipani,Leonard Guarente +9 more
TL;DR: It is concluded that SIRT1 deacetylates β‐catenin to promote its accumulation in the nucleus leading to transcription of genes for MSC differentiation, thereby restoring nuclear localization and differentiation potential in MSCKO cells.
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Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.
Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Enériz,Leire Garate,Eva Bandrés,Lucia Cordeu,Oscar Aparicio,Borja Saez,German Navarro,Amaia Vilas-Zornoza,Ignacio Pérez-Roger,Jesús García-Foncillas,Antoni Torres,Anabel Heiniger,María José Calasanz,Puri Fortes,Jose Roman-Gomez,Felipe Prosper +17 more
TL;DR: The results indicate that down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of CML implicating a miRNA in the abnormal behavior of C ML.