C
Carl D. Holmgren
Researcher at VU University Amsterdam
Publications - 14
Citations - 1561
Carl D. Holmgren is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Excitatory postsynaptic potential & Postsynaptic potential. The author has an hindex of 13, co-authored 14 publications receiving 1467 citations. Previous affiliations of Carl D. Holmgren include INMED & Karolinska Institutet.
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Journal ArticleDOI
Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
TL;DR: It is suggested that computation in the local network may proceed not only by direct pyramidal‐pyramidal cell communication but also via local interneurons, ideally poised to both coordinate and expand the local pyramid cell network via pyramID‐ interneuron‐ pyramides communication.
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Increased Threshold for Spike-Timing-Dependent Plasticity Is Caused by Unreliable Calcium Signaling in Mice Lacking Fragile X Gene Fmr1
TL;DR: In the prefrontal cortex of FMR1-KO mice, spike-timing-dependent long-term potentiation (tLTP) is not so much absent, but rather, the threshold for tLTP induction is increased as discussed by the authors.
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Coincident Spiking Activity Induces Long-Term Changes in Inhibition of Neocortical Pyramidal Cells
Carl D. Holmgren,Yuri Zilberter +1 more
TL;DR: It is shown that temporally correlated spiking activity of a pyramidal cell and an inhibiting interneuron may cause LTD or LTP of unitary IPSPs, and thatarity of change in synaptic efficacy depends on timing between Ca2+ influx induced by a backpropagating train of action potentials (APs) and subsequent activation of inhibitory synapses.
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Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex: Involvement of Vesicular Glutamate Transporter 3
Tibor Harkany,Carl D. Holmgren,Wolfgang Härtig,Tayyaba Qureshi,Farrukh A. Chaudhry,Jon Storm-Mathisen,Marton B. Dobszay,Paul Berghuis,Gunnar Schulte,Kyle M. Sousa,Robert T. Fremeau,Robert H. Edwards,Ken Mackie,Patrik Ernfors,Yuri Zilberter +14 more
TL;DR: It is demonstrated, using multiple immunofluorescence labeling and confocal laser-scanning microscopy, that VGLUT3-like immunoreactivity is present in dendrites of layer 2/3 pyramidal neurons in the rat neocortex, and it is demonstrated that glutamate can act as a retrograde messenger in the CNS.
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Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype
Patricia Klemmer,Rhiannon M. Meredith,Carl D. Holmgren,Oleg I. Klychnikov,Jianru Stahl-Zeng,Maarten Loos,Roel C. van der Schors,Joke Wortel,Heidi de Wit,Sabine Spijker,Diana C. Rotaru,Huibert D. Mansvelder,August B. Smit,Ka Wan Li +13 more
TL;DR: In this article, the authors used a quantitative proteomics approach in an FXS mouse model to reveal changes in levels of hippocampal synapse proteins, including Basp1 and Gap43, known PKC substrates, and Cend1.