Paul Berghuis

TL;DR: This work reports that CB1 cannabinoid receptors are enriched in the axonal growth cones of γ-aminobutyric acid–containing interneurons in the rodent cortex during late gestation and demonstrates that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.

TL;DR: Recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development are summarized.

TL;DR: It is found that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF, and eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by SRC kinase inhibition in vitro.

TL;DR: By generating specific antibodies against SAT1 it is shown that this glutamine carrier is particularly enriched in GABAergic neurons, suggesting that SAT1 can be involved in translocating glutamine into GABAergic neuron to facilitate inhibitory neurotransmitter generation.

TL;DR: It is demonstrated, using multiple immunofluorescence labeling and confocal laser-scanning microscopy, that VGLUT3-like immunoreactivity is present in dendrites of layer 2/3 pyramidal neurons in the rat neocortex, and it is demonstrated that glutamate can act as a retrograde messenger in the CNS.