R
Roel C. van der Schors
Researcher at VU University Amsterdam
Publications - 48
Citations - 3468
Roel C. van der Schors is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Lymnaea stagnalis & Synapse. The author has an hindex of 30, co-authored 47 publications receiving 3214 citations. Previous affiliations of Roel C. van der Schors include University of Amsterdam.
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Journal ArticleDOI
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
August B. Smit,Naweed I. Syed,Dick Schaap,Jan van Minnen,Judith Klumperman,Karel S. Kits,Hans Lodder,Roel C. van der Schors,René van Elk,Bertram Sorgedrager,Katjuša Brejc,Titia K. Sixma,Wijnand P. M. Geraerts +12 more
TL;DR: A molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft is described, and a model for how they actively regulate cholinergic transmission between neurons in the central nervous system is proposed.
Journal ArticleDOI
Proteomics Analysis of Rat Brain Postsynaptic Density IMPLICATIONS OF THE DIVERSE PROTEIN FUNCTIONAL GROUPS FOR THE INTEGRATION OF SYNAPTIC PHYSIOLOGY
Ka Wan Li,Martin Hornshaw,Roel C. van der Schors,Rod B. Watson,Stephen Tate,Bruno Casetta,Connie R. Jimenez,Yvonne Gouwenberg,Eckart D. Gundelfinger,Karl-Heinz Smalla,August B. Smit +10 more
TL;DR: In this paper, two-dimensional gel electrophoresis separation of proteins in conjunction with mass spectrometry to identify the tryptic peptides of the protein spots and isolation of the trypsin-digested sample that was labeled with isotope-coded affinity tag, were performed.
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Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking.
Michel C. van den Oever,Natalia A. Goriounova,Ka Wan Li,Roel C. van der Schors,Rob Binnekade,Anton N. M. Schoffelmeer,Huibert D. Mansvelder,August B. Smit,Sabine Spijker,Taco J. De Vries +9 more
TL;DR: It is shown that reexposure to cues previously associated with heroin results in downregulation of AMPA receptor subunit GluR2 and concomitant upregulation of clathrin-coat assembly protein AP2m1 in synaptic membranes of the medial prefrontal cortex (mPFC).
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Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Cornelis P. Tensen,Jacoba Flier,Elizabeth M.H. van der Raaij-Helmer,Shakun C. Sampat-Sardjoepersad,Roel C. van der Schors,Rob Leurs,Rik J. Scheper,D.M. Boorsma,Rein Willemze +8 more
TL;DR: In situ hybridization experiments showed that interferon-gamma-inducible protein-9 mRNA is expressed by basal layer keratinocytes in a variety of skin disorders, including allergic contact dermatitis, lichen planus, and mycosis fungoides suggesting a functional role for this chemokine in skin immune responses.
Journal ArticleDOI
The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.
Ana Saurí,Zora Soprova,David Wickström,Jan-Willem de Gier,Roel C. van der Schors,August B. Smit,Wouter S. P. Jong,Joen Luirink +7 more
TL;DR: A stalled translocation intermediate of the autotransporter Hbp is used to identify components involved in insertion and translocation of the protein across the outer membrane and suggests a critical role for this general machinery in the translocation and insertion and assembly of outer-membrane proteins.