Carles Tapias-Espinosa

TL;DR: The results support the notion that sensorimotor gating is modulated by forebrain structures and highlight the importance of the mPFC in its regulation and suggest that, apart from a hypoactive and smaller mP FC, a hyperactive NAc and smaller HPC may underlie reduced PPI levels.

TL;DR: It was found that, compared with their RLA counterparts, RHA rats show increased exploration of the novel object in the NOE test, lowered anxiety in the ZM and impaired PPI, whereas RLAs display better spatial reference learning and memory and better cognitive flexibility in a reversal task.

TL;DR: The data suggest that such a consistent association between impaired PPI and increased exploratory activity in outbred HS and inbred RHA/RLA rats is a relevant parameter that must be taken into account when modeling clusters of schizophrenia-relevant symptoms.

TL;DR: Results showed a global increase in volume in the mPFC in the isolated rats of both strains, as well as strain effects (RLA > RHA) in the three brain regions, which might have unveiled some kind of compensatory mechanisms due to the particularly long-lasting isolation rearing period.

TL;DR: Post-ET between-strain differences in avoidance acquisition, context-conditioned freezing and novelty-induced self-grooming are conserved, suggesting that the pre-/post-natal environment may have influenced these co-segregated traits at G1, though further selection pressure along the subsequent generations rescues the typical strain-related differences.