Carlo Brugnara

TL;DR: In this article, the authors characterized the Gardos channel function in vitro and in vivo in erythrocytes of 4.1-/- mice, and showed that the increased sensitivity to activation by intracellular calcium indicates an increased sensitivity of the channel to intraclass calcium, which may play an important role in compensating for the reduced surface-membrane area of hereditary spherocytosis.

TL;DR: It is observed that the same gene or group of genes influences both WBC count and mean platelet volume, and it is anticipated that this approach will ultimately lead to discovery of novel insights into the biology of related traits, and ultimately identify important genes that affect hematopoiesis.

TL;DR: Reverse cation-leak stomatocytosis mutant AE1 R730C exhibits severely reduced anion transport unaccompanied by increased Rb(+) and Li(+) influxes, and residue R730 is defined as critical to selectivity and regulation of anions transport by AE1.

TL;DR: In Ptpre−/−mouse RBCs, the activity of Fyn was increased while Syk kinase activity was decreased compared to wild‐type R BCs, validating the network computational analysis, and indicating a novel signaling pathway, which involves Fyn and Syk in regulation of red cell morphology.

TL;DR: F superfusion of strips of portal vein VSM with CLT enhanced isometric tension and spontaneous rate of contraction, suggesting that CLT modulation of maxi-K currents may alter vasomotor functioning.