Carlo Brugnara

TL;DR: The results suggest that the use of AMPS combined with machine learning provides an approach to developing point-of-care hematology, and predict several important red blood cell parameters, such as mean corpuscular hemoglobin concentration.

TL;DR: Electro microscopic studies of plasma and red cells of subjects receiving SC rEPO showed the presence of circulating exosomes and cytoplasmic multivesicular bodies, thereby providing evidence that, as do nonhuman red cells, maturing human reticulocytes shed exosome‐associated transferrin receptors.

TL;DR: Studies on the regulation of cell volume and water and cation content in sickle cells are important for two reasons: first, the extreme dependence of H b S polymerization on Hb S concentration is an important potential target for pharmacological approaches to the therapy of sickle cell disease, and second, these studies are necessary to understand the nature and determinants of the process leading to formation of dense, dehydrated cells in the blood of Sickle cell anemia patients.

TL;DR: In this article, a two-step pathogenesis model was proposed: cell-intrinsic downregulation of core FOXP3-dependent genes destabilizes Treg cells, de-repressing systemic mediators that imprint the disease signature on all T cells, furthering Treg cell dysfunction.

TL;DR: There was no evidence that hydroxyurea was associated with increased urine concentrating ability in children with Hb SC disease, and results may reflect irreversible renal medullary damage prior to beginning treatment or insufficient intensity or duration of treatment.