C
Carlo Brugnara
Researcher at Boston Children's Hospital
Publications - 348
Citations - 20837
Carlo Brugnara is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Red blood cell & Iron deficiency. The author has an hindex of 76, co-authored 333 publications receiving 19351 citations. Previous affiliations of Carlo Brugnara include Albert Einstein College of Medicine & University of Kansas.
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Journal ArticleDOI
Screening healthy infants for iron deficiency using reticulocyte hemoglobin content.
Christina Ullrich,Ann Wu,C. C. Armsby,Sarah Rieber,Sarah L. Wingerter,Carlo Brugnara,David Shapiro,Henry H. Bernstein +7 more
TL;DR: Reticulocyte hemoglobin content (CHr) is a more accurate hematological indicator of iron deficiency compared with hemoglobin of less than 11 g/dL in these healthy 9- to 12-month-old infants and is associated with subsequent anemia when screened again in the second year of life.
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Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
Elisa Boscolo,Elisa Boscolo,Nisha Limaye,Lan Huang,Kyu Tae Kang,Kyu Tae Kang,Julie Soblet,Mélanie Uebelhoer,Antonella Mendola,Marjut Nätynki,Emmanuel Seront,Sophie Dupont,Jennifer Hammer,Catherine Legrand,Carlo Brugnara,Lauri Eklund,Miikka Vikkula,Joyce Bischoff,Laurence M. Boon +18 more
TL;DR: A VM model is generated that allows evaluation of potential therapeutic strategies and demonstrates that rapamycin provides clinical improvement in patients with venous malformation.
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Reticulocyte cellular indices: a new approach in the diagnosis of anemias and monitoring of erythropoietic function.
TL;DR: Reticulocyte hemoglobin content (CHr) may allow prompt identification of an imbalance between r-HuEPO therapy and iron availability by detecting the presence in reticulocytes of iron-restricted erythropoiesis and Response to therapy of megaloblastic anemia can be monitored with CHr.
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Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery
John N. Kheir,Laurie A. Scharp,Mark A. Borden,Mark A. Borden,Edward J. Swanson,Andrew Loxley,James Reese,Katherine J. Black,Luis A. Velazquez,Lindsay M. Thomson,Brian K Walsh,Kathryn E. Mullen,Dionne A. Graham,Michael W. Lawlor,Carlo Brugnara,David C. Bell,Francis X. McGowan,Francis X. McGowan +17 more
TL;DR: An injectable foam suspension containing self-assembling, lipid-based microparticles encapsulating a core of pure oxygen gas for intravenous injection that significantly decreased the degree of hypoxemia in rabbits and lived longer and did not experience any injury to major organs, such as liver and lungs.
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Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI
Teresa M. Holm,Anne Braun,Bernardo L. Trigatti,Carlo Brugnara,Masa Sakamoto,Monty Krieger,Nancy C. Andrews +6 more
TL;DR: It is proposed that autophagocytosis and phagolysosome expulsion are essential steps in erythroid maturation and that expulsion is inhibited in the presence of markedly increased cellular cholesterol.