C
Carlo Laudanna
Researcher at University of Verona
Publications - 128
Citations - 11670
Carlo Laudanna is an academic researcher from University of Verona. The author has contributed to research in topics: Integrin & RHOA. The author has an hindex of 38, co-authored 118 publications receiving 10830 citations. Previous affiliations of Carlo Laudanna include United States Department of Veterans Affairs & Stanford University.
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
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Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow.
Gabriela Constantin,Meytham Majeed,Cinzia Giagulli,Laura Piccio,Ji Yun Kim,Eugene C. Butcher,Carlo Laudanna +6 more
TL;DR: It is shown that the chemokines SLC, ELC, and SDF-1alpha rapidly induce lateral mobility and transient increase of affinity of the beta2 integrin LFA-1 that can coordinately determine the vascular arrest of circulating lymphocytes under physiologic conditions.
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Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins
TL;DR: Findings suggest that Rho participates in signaling from chemoattractant receptors to trigger rapid adhesion in leukocytes, and is involved in immune cell-cell interactions and trafficking.
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Analyzing biological network parameters with CentiScaPe
TL;DR: The Cytoscape plug-in CentiScaPe provides a Boolean logic-based tool that allows easy characterization of nodes whose topological relevance depends on more than one centrality, thus allowing easy node categorization and experimental prioritization.
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GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
Tibor Kempf,Alexander Zarbock,Christian Widera,Stefan Butz,Anika Stadtmann,Jan Rossaint,Matteo Bolomini-Vittori,Mortimer Korf-Klingebiel,L. Christian Napp,Birte Hansen,Anna Kanwischer,Udo Bavendiek,Gernot Beutel,Martin Hapke,Martin Sauer,Carlo Laudanna,Nancy Hogg,Dietmar Vestweber,Kai C. Wollert +18 more
TL;DR: GDF-15 is the first cytokine identified as an inhibitor of PMN recruitment by direct interference with chemokine signaling and integrin activation, and loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction.