Ontologies tend to be found everywhere. They are viewed as the silver bullet for many applications, such as database integration, peer-to-peer systems, e-commerce, semantic web services, or social networks. However, in open or evolving systems, such as the semantic web, different parties would, in general, adopt different ontologies. Thus, merely using ontologies, like using XML, does not reduce heterogeneity: it just raises heterogeneity problems to a higher level. Euzenat and Shvaikos book is devoted to ontology matching as a solution to the semantic heterogeneity problem faced by computer systems. Ontology matching aims at finding correspondences between semantically related entities of different ontologies. These correspondences may stand for equivalence as well as other relations, such as consequence, subsumption, or disjointness, between ontology entities. Many different matching solutions have been proposed so far from various viewpoints, e.g., databases, information systems, and artificial intelligence. The second edition of Ontology Matching has been thoroughly revised and updated to reflect the most recent advances in this quickly developing area, which resulted in more than 150 pages of new content. In particular, the book includes a new chapter dedicated to the methodology for performing ontology matching. It also covers emerging topics, such as data interlinking, ontology partitioning and pruning, context-based matching, matcher tuning, alignment debugging, and user involvement in matching, to mention a few. More than 100 state-of-the-art matching systems and frameworks were reviewed. With Ontology Matching, researchers and practitioners will find a reference book that presents currently available work in a uniform framework. In particular, the work and the techniques presented in this book can be equally applied to database schema matching, catalog integration, XML schema matching and other related problems. The objectives of the book include presenting (i) the state of the art and (ii) the latest research results in ontology matching by providing a systematic and detailed account of matching techniques and matching systems from theoretical, practical and application perspectives.

Ontology Matching

The Gene Ontology (GO; http://wwwgeneontologyorg) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology

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Gene Ontology Consortium: going forward

The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its contents are under continual improvement, both in quantity and in quality. Here, we report the major developments of the GO resource during the past two years. Each monthly release of the GO resource is now packaged and given a unique identifier (DOI), enabling GO-based analyses on a specific release to be reproduced in the future. The molecular function ontology has been refactored to better represent the overall activities of gene products, with a focus on transcription regulator activities. Quality assurance efforts have been ramped up to address potentially out-of-date or inaccurate annotations. New evidence codes for high-throughput experiments now enable users to filter out annotations obtained from these sources. GO-CAM, a new framework for representing gene function that is more expressive than standard GO annotations, has been released, and users can now explore the growing repository of these models. We also provide the ‘GO ribbon’ widget for visualizing GO annotations to a gene; the widget can be easily embedded in any web page.

The Gene Ontology Resource: 20 years and still GOing strong

Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body We find that few genes are truly 'housekeeping', whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research

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A promoter-level mammalian expression atlas

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity.

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A communal catalogue reveals Earth’s multiscale microbial diversity

This paper presents multimedia ontologies, where visual prototypes are added as specialization of concepts defined in a traditional linguistic ontology. The more general concepts of the sport domain (e.g. play/break, crowd, etc.) are put in correspondence with the more general visual features of the video like color and texture, while the more specific concepts of the soccer domain (e.g. highlights such as attack actions) are put in correspondence with domain specific visual feature like the soccer playfield and the players. A solution for the implementation of multimedia ontologies for the soccer video domain and a method to perform automatic soccer video annotation using these extended ontologies is shown. Experimental results for automatic annotation of soccer videos containing generic concepts are presented.

Soccer Video Annotation Using Ontologies Extended with Visual Prototypes

This paper presents multimedia ontologies, where multimedia data and traditional textual ontologies are merged. A solution for their implementation for the soccer video domain and a method to perform automatic soccer video annotation using these extended ontologies is shown. HSV is a widely adopted space in image and video retrieval, but its quantization for histogram generation can create misleading errors in classification of achromatic and low saturated colors. In this paper we propose an enhanced HSV histogram with achromatic point detection based on a single hue and saturation parameter that can correct this limitation. The more general concepts of the sport domain (e.g. play/break, crowd, etc.) are put in correspondence with the more general visual features of the video like color and texture, while the more specific concepts of the soccer domain (e.g. highlights such as attack actions) are put in correspondence with domain specific visual feature like the soccer playfield and the players. Experimental results for annotation of soccer videos using generic concepts are presented.

Sports Video Annotation Using Enhanced HSV Histograms in Multimedia Ontologies

In this paper we present the linked data sets produced by the eagle-i project. We describe the content, the features and some of the applications currently leveraging these datasets.

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eagle-i: Biomedical research resource datasets

In recent years the growth in popularity of digital photography, together with the availability of GPS devices and the developing in web technologies have extended the possibilities for managing and sharing large numbers of geotagged pictures. Among the huge number of possible applications that may link and discover geotagged resources, we present a prototype system in which an RDF description of pictures, including location and compass heading information, is used to discover geo-related pictures of a same city taken from different users. We propose a browsing interface, based on different levels of relationship between pictures metadata, that allows users to explore cities according to the relations discovered.

The Big Picture: Exploring Cities through Georeferenced Images and RDF Shared Metadata

A key challenge for improving the quality of health care is to be able to use a common framework to work with patient information acquired in any of the health and life science disciplines. Patient information collected during dental care exposes many of the challenges that confront a wider scale approach. For example, to improve the quality of dental care, we must be able to collect and analyze data about dental procedures from multiple practices. However, a number of challenges make doing so difficult. First, dental electronic health record (EHR) information is often stored in complex relational databases that are poorly documented. Second, there is not a commonly accepted and implemented database schema for dental EHR systems. Third, integrative work that attempts to bridge dentistry and other settings in healthcare is made difficult by the disconnect between representations of medical information within dental and other disciplines’ EHR systems. As dentistry increasingly concerns itself with the general health of a patient, for example in increased efforts to monitor heart health and systemic disease, the impact of this disconnect becomes more and more severe. To demonstrate how to address these problems, we have developed the open-source Oral Health and Disease Ontology (OHD) and our instance-based representation as a framework for dental and medical health care information. We envision a time when medical record systems use a common data back end that would make interoperating trivial and obviate the need for a dedicated messaging framework to move data between systems. The OHD is not yet complete. It includes enough to be useful and to demonstrate how it is constructed. We demonstrate its utility in an analysis of longevity of dental restorations. Our first narrow use case provides a prototype, and is intended demonstrate a prospective design for a principled data backend that can be used consistently and encompass both dental and medical information in a single framework. The OHD contains over 1900 classes and 59 relationships. Most of the classes and relationships were imported from existing OBO Foundry ontologies. Using the LSW2 (LISP Semantic Web) software library, we translated data from a dental practice’s EHR system into a corresponding Web Ontology Language (OWL) representation based on the OHD framework. The OWL representation was then loaded into a triple store, and as a proof of concept, we addressed a question of clinical relevance – a survival analysis of the longevity of resin filling restorations. We provide queries using SPARQL and statistical analysis code in R to demonstrate how to perform clinical research using a framework such as the OHD, and we compare our results with previous studies. This proof-of-concept project translated data from a single practice. By using dental practice data, we demonstrate that the OHD and the instance-based approach are sufficient to represent data generated in real-world, routine clinical settings. While the OHD is applicable to integration of data from multiple practices with different dental EHR systems, we intend our work to be understood as a prospective design for EHR data storage that would simplify medical informatics. The system has well-understood semantics because of our use of BFO-based realist ontology and its representation in OWL. The data model is a well-defined web standard.

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Carlo Torniai

Papers

Soccer Video Annotation Using Ontologies Extended with Visual Prototypes

Sports Video Annotation Using Enhanced HSV Histograms in Multimedia Ontologies

eagle-i: Biomedical research resource datasets

The Big Picture: Exploring Cities through Georeferenced Images and RDF Shared Metadata

Structuring, reuse and analysis of electronic dental data using the Oral Health and Disease Ontology