C
Carlos A. Sariol
Researcher at University of Puerto Rico, Medical Sciences Campus
Publications - 56
Citations - 1304
Carlos A. Sariol is an academic researcher from University of Puerto Rico, Medical Sciences Campus. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 18, co-authored 48 publications receiving 1102 citations. Previous affiliations of Carlos A. Sariol include University of Tübingen & Pan American Health Organization.
Papers
More filters
Journal ArticleDOI
Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
Petraleigh Pantoja,Erick X. Pérez-Guzmán,Idia V. Rodríguez,Laura J. White,Olga González,Crisanta Serrano,Luis D. Giavedoni,Vida L. Hodara,Lorna Cruz,Teresa Arana,Melween I. Martínez,Mariah Hassert,James D. Brien,Amelia K. Pinto,Aravinda M. de Silva,Carlos A. Sariol +15 more
TL;DR: The results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZikV pathogenesis.
Journal ArticleDOI
Partial nucleotide and amino acid sequences of the envelope and the envelope/nonstructural protein-1 gene junction of four dengue-2 virus strains isolated during the 1981 Cuban epidemic.
María G. Guzmán,Vincent Deubel,José L. Pelegrino,Delfina Rosario,Miguel Marrero,Carlos A. Sariol,Gustavo Kourí +6 more
TL;DR: The E segment of these 1981 Cuban isolates were more closely related to older dengue-2 virus strains such as New Guinea C 1944, Thailand 1964, Sri Lanka 1968, and Burma 1976 than to more recent isolates of this virus from Jamaica and Vietnam.
Journal ArticleDOI
A New Quaternary Structure Epitope on Dengue Virus Serotype 2 Is the Target of Durable Type-Specific Neutralizing Antibodies
Emily N. Gallichotte,Douglas G. Widman,Boyd Yount,Wahala M.P.B. Wahala,Anna P. Durbin,Steve S. Whitehead,Carlos A. Sariol,James E. Crowe,A. M. de Silva,Ralph S. Baric +9 more
TL;DR: The ability to transplant a complex epitope between DENV serotypes demonstrates a hitherto underappreciated structural flexibility in flaviviruses, which could be harnessed to develop new vaccines and diagnostics.
Journal ArticleDOI
An Alphavirus Vector-Based Tetravalent Dengue Vaccine Induces a Rapid and Protective Immune Response in Macaques That Differs Qualitatively from Immunity Induced by Live Virus Infection
Laura J. White,Carlos A. Sariol,Melissa D. Mattocks,Wahala M.P.B. Wahala,Vorraphun Yingsiwaphat,Martha Collier,Jill Whitley,Rochelle Mikkelsen,Idia V. Rodríguez,Melween I. Martínez,Aravinda D. De Silva,Robert E. Johnston +11 more
TL;DR: This study is the first to map antigenic domains and specificities targeted by vaccination versus natural infection, revealing that, unlike prME-VRP and live virus, E85-VRp induced only serotype-specific antibodies, which predominantly targeted EDIII, suggesting a protective mechanism different from that induced by live virus and possibly live attenuated vaccines.
Journal ArticleDOI
Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses
Kavitha Yaddanapudi,Gustavo Palacios,Jonathan S. Towner,Ivy Chen,Carlos A. Sariol,Stuart T. Nichol,W. Ian Lipkin +6 more
TL;DR: Findings are consistent with the observation that REBOV is not pathogenic in humans, apes, and monkeys and have implications for understanding the pathogenesis of filoviral HF.