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Petraleigh Pantoja
Researcher at University of Puerto Rico, Medical Sciences Campus
Publications - 24
Citations - 517
Petraleigh Pantoja is an academic researcher from University of Puerto Rico, Medical Sciences Campus. The author has contributed to research in topics: Dengue virus & Antibody. The author has an hindex of 6, co-authored 18 publications receiving 386 citations. Previous affiliations of Petraleigh Pantoja include University of Puerto Rico.
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Journal ArticleDOI
Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
Petraleigh Pantoja,Erick X. Pérez-Guzmán,Idia V. Rodríguez,Laura J. White,Olga González,Crisanta Serrano,Luis D. Giavedoni,Vida L. Hodara,Lorna Cruz,Teresa Arana,Melween I. Martínez,Mariah Hassert,James D. Brien,Amelia K. Pinto,Aravinda M. de Silva,Carlos A. Sariol +15 more
TL;DR: The results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZikV pathogenesis.
Journal ArticleDOI
Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques.
Carlos A. Sariol,Melween I. Martínez,Francheska Rivera,Idia V. Rodríguez,Petraleigh Pantoja,Kristina Abel,Teresa Arana,Luis D. Giavedoni,Vida L. Hodara,Laura J. White,Yesseinia I. Angleró,Luis J. Montaner,Edmundo Kraiselburd +12 more
TL;DR: Data show that concurrent TLR3/7/8 activation of the innate immune response after DENV infection in vivo acts to increase antiviral mechanisms via increased inflammatory and humoral responses in rhesus macaques, resulting in decreased viremia and melioration of the infection.
Journal ArticleDOI
Dengue Virus Subverts the Interferon Induction Pathway via NS2B/3 Protease-IκB Kinase ε Interaction
TL;DR: It is shown that dengue virus (DENV) circumvents the induction of the retinoic acid-inducible gene I-like receptor (RLR) pathway during infection by blocking serine 386 phosphorylation and nuclear translocation of IRF3.
Journal ArticleDOI
Transcriptional Activation of Interferon-Stimulated Genes but Not of Cytokine Genes after Primary Infection of Rhesus Macaques with Dengue Virus Type 1
Carlos A. Sariol,Jorge L. Muñoz-Jordán,Kristina Abel,Lymarie C. Rosado,Petraleigh Pantoja,Luis D. Giavedoni,Idia V. Rodríguez,Laura J. White,Melween I. Martínez,Teresa Arana,Edmundo Kraiselburd +10 more
TL;DR: The broad transcriptional modifications and cytokine expression profile after infecting rhesus macaques with DENV serotype 1 was studied by using Affymetrix oligonucleotide microarrays and no up-regulation of IFN-α, -β, or -γ genes was detected.
Posted ContentDOI
The receptor binding domain of SARS-CoV-2 spike is the key target of neutralizing antibody in human polyclonal sera
Tara L. Steffen,E. Taylor Stone,Mariah Hassert,Elizabeth Geerling,Brian T. Grimberg,Ana M. Espino,Petraleigh Pantoja,Consuelo Climent,Daniel F. Hoft,Sarah L. George,Carlos A. Sariol,Amelia K. Pinto,James D. Brien +12 more
TL;DR: It is shown that epitopes within RBD are the target of a majority of the neutralizing antibodies in the human polyclonal antibody response, which provides critical information for vaccine development and development of sensitive and specific serological testing.