Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications

Nanomaterials, such as metal or semiconductor nanoparticles and nanorods, exhibit similar dimensions to those of biomolecules, such as proteins (enzymes, antigens, antibodies) or DNA. The integration of nanoparticles, which exhibit unique electronic, photonic, and catalytic properties, with biomaterials, which display unique recognition, catalytic, and inhibition properties, yields novel hybrid nanobiomaterials of synergetic properties and functions. This review describes recent advances in the synthesis of biomolecule-nanoparticle/nanorod hybrid systems and the application of such assemblies in the generation of 2D and 3D ordered structures in solutions and on surfaces. Particular emphasis is directed to the use of biomolecule-nanoparticle (metallic or semiconductive) assemblies for bioanalytical applications and for the fabrication of bioelectronic devices.

Integrated Nanoparticle–Biomolecule Hybrid Systems: Synthesis, Properties, and Applications

Magnetic Nanoparticles in MR Imaging and Drug Delivery

Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior and indispensable in many areas of human activity. This brief review tries to summarise the most recent developments in the field of applied nanomaterials, in particular their application in biology and medicine, and discusses their commercialisation prospects.

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Applications of nanoparticles in biology and medicine

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.

https://iopscience.iop.org/article/10.1088/0022-3727/36/13/201/pdf

Applications of magnetic nanoparticles in biomedicine

Monodisperse spherical FeCo nanoparticles were synthesized by reduction decomposition of Fe(acac)3 and Co(acac)2 in the presence of surfactants and 1,2-hexadecanediol. The particle size can be controlled by varying the surfactants. The presence of surfactants on the surface of the nanocrystal protects them from surface oxidation. The saturation magnetization of as-synthesized particles is found to be size dependent. The as-synthesized FeCo nanoparticles can be made air-stable by annealing at 500 °C for 30 min without causing particles sintering.

Carlos Bárcena

Papers

Applications of magnetic nanoparticles in biomedicine

Synthesis and stabilization of FeCo nanoparticles.

Zinc ferrite nanoparticles as MRI contrast agents