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Carlos J. Ticas
Researcher at Boston University
Publications - 2
Citations - 177
Carlos J. Ticas is an academic researcher from Boston University. The author has contributed to research in topics: Mitosis. The author has an hindex of 2, co-authored 2 publications receiving 41 citations.
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Journal ArticleDOI
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Ryan J. Quinton,Amanda DiDomizio,Marc A. Vittoria,Kristýna Kotýnková,Carlos J. Ticas,Sheena Patel,Yusuke Koga,Jasmine Vakhshoorzadeh,Nicole M. Hermance,Taruho S. Kuroda,Neha Parulekar,Alison M. Taylor,Amity L. Manning,Joshua D. Campbell,Joshua D. Campbell,Neil J. Ganem +15 more
TL;DR: This paper showed that WGD+ cells are more dependent than WGD-cells on signalling from the spindle-assembly checkpoint, DNA-replication factors and proteasome function and identified KIF18A, which encodes a mitotic kinesin protein, as being specifically required for the viability of whole-genome doubling (WGD+) cells.
Posted ContentDOI
Whole genome doubling confers unique genetic vulnerabilities on tumor cells
Ryan J. Quinton,Amanda DiDomizio,Marc A. Vittoria,Carlos J. Ticas,Sheena Patel,Yusuke Koga,Kristyna Kotynkova,Jasmine Vakhshoorzadeh,Nicole M. Hermance,Taruho S. Kuroda,Neha Parulekar,Alison M. Taylor,Amity L. Manning,Joshua D. Campbell,Neil J. Ganem +14 more
TL;DR: It is shown that WGD gives rise to common genetic traits that are accompanied by unique vulnerabilities, and KIF18A, which encodes for a mitotic kinesin, is identified as being specifically required for the viability of WGD+ cells.