Nicole M. Hermance

TL;DR: This paper showed that WGD+ cells are more dependent than WGD-cells on signalling from the spindle-assembly checkpoint, DNA-replication factors and proteasome function and identified KIF18A, which encodes a mitotic kinesin protein, as being specifically required for the viability of whole-genome doubling (WGD+) cells.

TL;DR: It is shown that WGD gives rise to common genetic traits that are accompanied by unique vulnerabilities, and KIF18A, which encodes for a mitotic kinesin, is identified as being specifically required for the viability of WGD+ cells.

TL;DR: It is demonstrated that loss of STK25 promotes YAP/TAZ activation and enhanced cellular proliferation, even under normally growth-suppressive conditions both in vitro and in vivo, and is significantly focally deleted across a wide spectrum of human cancers.

TL;DR: Alisertib is well tolerated when combined with induction chemotherapy in acute myeloid leukemia, and this efficacy appears enhanced in combination with conventional chemotherapies.

TL;DR: It is demonstrated that Aurora A kinase activity is required for spindle pole clustering in cells with extra centrosomes, suggesting that centrosome number and spindle polarity may serve as predictive biomarkers for response to therapeutic approaches that target Aurora A Kinase function.