K
Kristýna Kotýnková
Researcher at Boston University
Publications - 1
Citations - 112
Kristýna Kotýnková is an academic researcher from Boston University. The author has an hindex of 1, co-authored 1 publications receiving 33 citations.
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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Ryan J. Quinton,Amanda DiDomizio,Marc A. Vittoria,Kristýna Kotýnková,Carlos J. Ticas,Sheena Patel,Yusuke Koga,Jasmine Vakhshoorzadeh,Nicole M. Hermance,Taruho S. Kuroda,Neha Parulekar,Alison M. Taylor,Amity L. Manning,Joshua D. Campbell,Joshua D. Campbell,Neil J. Ganem +15 more
TL;DR: This paper showed that WGD+ cells are more dependent than WGD-cells on signalling from the spindle-assembly checkpoint, DNA-replication factors and proteasome function and identified KIF18A, which encodes a mitotic kinesin protein, as being specifically required for the viability of whole-genome doubling (WGD+) cells.