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Amity L. Manning
Researcher at Worcester Polytechnic Institute
Publications - 39
Citations - 3417
Amity L. Manning is an academic researcher from Worcester Polytechnic Institute. The author has contributed to research in topics: Mitosis & Spindle apparatus. The author has an hindex of 20, co-authored 36 publications receiving 2917 citations. Previous affiliations of Amity L. Manning include Brandeis University & Dartmouth College.
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Journal ArticleDOI
A novel retinoblastoma therapy from genomic and epigenetic analyses
Jinghui Zhang,Claudia A. Benavente,Justina McEvoy,Jacqueline Flores-Otero,Li Ding,Xiang Chen,Anatoly Ulyanov,Gang Wu,Matthew W. Wilson,Matthew W. Wilson,Jianmin Wang,Rachel C. Brennan,Michael Rusch,Amity L. Manning,Jing Ma,John Easton,Sheila A. Shurtleff,Charles G. Mullighan,Stanley Pounds,Suraj Mukatira,Pankaj Gupta,Geoff Neale,David Zhao,Charles Lu,Robert S. Fulton,Lucinda Fulton,Xin Hong,David J. Dooling,Kerri Ochoa,Clayton W. Naeve,Nicholas J. Dyson,Elaine R. Mardis,Armita Bahrami,David H. Ellison,Richard K. Wilson,James R. Downing,Michael A. Dyer,Michael A. Dyer +37 more
TL;DR: It is shown that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated, and that the proto-oncogene SYK is upregulated in retinOBlastoma and is required for tumour cell survival.
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Genome stability is ensured by temporal control of kinetochore–microtubule dynamics
TL;DR: It is shown that two microtubule-depolymerizing kinesins, Kif2b and MCAK, stimulate kinetochore–microtubule dynamics during distinct phases of mitosis to correct mal-orientations, establishing a causal relationship between deregulation of kinetechore– microtubules dynamics and chromosomal instability.
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A Conserved Mechanism for Bni1- and mDia1-induced Actin Assembly and Dual Regulation of Bni1 by Bud6 and Profilin
James B. Moseley,Isabelle Sagot,Amity L. Manning,Yingwu Xu,Michael J. Eck,David Pellman,Bruce L. Goode +6 more
TL;DR: A model in which Bni1 FH2 dimers nucleate and processively cap the elongating barbed end of the actin filament, and Bud6 and profilin generate a local flux of ATP-actin monomers to promote actin assembly is proposed.
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Loss of pRB causes centromere dysfunction and chromosomal instability
TL;DR: Observations of chromosome segregation show that depletion of the retinoblastoma protein (pRB) causes rates of missegregation comparable with those seen in CIN tumor cells, and suggest that subtle defects in centromere function are a frequent source of merotely and CIN in cancer.
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The Kinesin-13 Proteins Kif2a, Kif2b, and Kif2c/MCAK Have Distinct Roles during Mitosis in Human Cells
Amity L. Manning,Neil J. Ganem,Samuel F. Bakhoum,Michael Wagenbach,Linda Wordeman,Duane A. Compton +5 more
TL;DR: It is demonstrated that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of K if2a, Kif 2b, and MCAK fulfill distinct functions during mitosis in human cells.