Ryan J. Quinton

TL;DR: This paper showed that WGD+ cells are more dependent than WGD-cells on signalling from the spindle-assembly checkpoint, DNA-replication factors and proteasome function and identified KIF18A, which encodes a mitotic kinesin protein, as being specifically required for the viability of whole-genome doubling (WGD+) cells.

TL;DR: It is shown that WGD gives rise to common genetic traits that are accompanied by unique vulnerabilities, and KIF18A, which encodes for a mitotic kinesin, is identified as being specifically required for the viability of WGD+ cells.

TL;DR: A direct link between the Hippo and mTORC1 pathways to fine-tune organ growth is revealed, with the LATS1 and LATS2 kinases phosphorylate the Raptor component Raptor to attenuate m TORC1 activation.

TL;DR: The nuclear envelope, composed of two lipid bilayers and numerous accessory proteins, has evolved to house the genetic material of all eukaryotic cells and once believed to be highly stable, is shown to be prone to rupture.

TL;DR: It is demonstrated that loss of STK25 promotes YAP/TAZ activation and enhanced cellular proliferation, even under normally growth-suppressive conditions both in vitro and in vivo, and is significantly focally deleted across a wide spectrum of human cancers.