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Carlos Requena
Researcher at Spanish National Research Council
Publications - 5
Citations - 84
Carlos Requena is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Internal medicine & Allosteric regulation. The author has an hindex of 3, co-authored 4 publications receiving 59 citations.
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Journal ArticleDOI
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease
Talita Perez Cantuaria Chierrito,Susimaire Pedersoli-Mantoani,Carlos Roca,Carlos Requena,Víctor Sebastián-Pérez,Willian Orlando Castillo,Natália Stanko Moreira,Concepción Pérez,Elza Tiemi Sakamoto-Hojo,Catarina Satie Takahashi,Jesús Jiménez-Barbero,F. Javier Cañada,Nuria E. Campillo,Ana Martínez,Ivone Carvalho +14 more
TL;DR: The design, synthesis and evaluation of non-toxic dual binding site AChEIs by hybridization of indanone and quinoline heterocyclic scaffolds are proposed and a potent allosteric modulator of AChe able to target cholinergic and non-cholinergic functions is found by fixing a specific AchE conformation.
Journal ArticleDOI
Identification of new allosteric sites and modulators of AChE through computational and experimental tools.
Carlos Roca,Carlos Requena,Víctor Sebastián-Pérez,Sony Malhotra,Chris J Radoux,Concepción Pérez,Ana Martínez,Juan A. Páez,Tom L. Blundell,Nuria E. Campillo +9 more
TL;DR: Two new allosteric sites in Acetylcholinesterase are identified using computational tools and may be valuable pharmacological tools in the study of non-cholinergic functions of AChE.
Journal ArticleDOI
Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses.
Fátima Lasala,Alfonso García-Rubia,Carlos Requena,Inmaculada Galindo,Miguel Ángel Cuesta-Geijo,Isabel García-Dorival,Paula Bueno,Nuria Labiod,Joanna Luczkowiak,Ana Martínez,Nuria E. Campillo,Covadonga Alonso,Rafael Delgado,Carmen Gil +13 more
TL;DR: In this article, a virtual screening was done on the druggable interaction between the EBOV glycoprotein and the host receptor NPC1 with a subsequent selection of compounds for further validation.
Journal ArticleDOI
Abstract 15424: The Toxic Tango: Tyrosine Kinase Inhibitors (TKI) and Immune Checkpoint Inhibitors (ICI) Toxicities
TL;DR: In this paper , a case of TKI-ICI toxicity resulting in multiorgan inflammatory syndrome with myocarditis and thrombotic STEMI was treated with high-dose steroids and PCI.
THE OTHER SIDE OF AChE: ALLOSTERIC SITES AND MODULATORS
Carlos Roca,Carlos Requena,Víctor Sebastián-Pérez,Sony Malhotra,Chris J Radoux,Concepción Pérez,Ana Martínez,Juan A. Páez,Tom L. Blundell,Nuria E. Campillo +9 more
TL;DR: New compounds have been developed as allosteric modulators that may be valuable pharmacological tools in the study of non-cholinergic functions of AChE.