C
Carmen Alaez
Researcher at Universidad de Guanajuato
Publications - 36
Citations - 838
Carmen Alaez is an academic researcher from Universidad de Guanajuato. The author has contributed to research in topics: Human leukocyte antigen & Population. The author has an hindex of 17, co-authored 36 publications receiving 806 citations. Previous affiliations of Carmen Alaez include Universidad Autónoma de Nuevo León.
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Journal ArticleDOI
The genetic structure of Mexican Mestizos of different locations: tracking back their origins through MHC genes, blood group systems, and microsatellites.
Clara Gorodezky,Carmen Alaez,Carmen Alaez,Miriam N Vázquez-Garcı́a,Miriam N Vázquez-Garcı́a,Gabriela de la Rosa,Gabriela de la Rosa,E. Infante,E. Infante,S Balladares,S Balladares,Rosa Toribio,Rosa Toribio,Elva Pérez-Luque,Elva Pérez-Luque,Linda Muñoz,Linda Muñoz +16 more
TL;DR: The results demonstrate the high variability resulting from interethnic admixture, suggesting that this mechanism is the main factor responsible for the large diversity found in urban populations.
Journal ArticleDOI
MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis
Miriam Vazquez-García,Carmen Alaez,A. Olivo,H. Debaz,Elva Pérez-Luque,Ana Burguete,Silvia Cano,Gabriela de la Rosa,Norma Bautista,Arturo Hernandez,José Bandera,Luis Torres,David Kershenobich,Fernando Alvarez,Clara Gorodezky +14 more
TL;DR: The possible mechanism of HLA association is due to "shared epitopes", since DRB 1*0404, and those found in other populations namely, DRB1*0401, *0405 and *0301 share almost the same sequence at position 67-72 (LLEQRR, R or K at 71).
Journal ArticleDOI
Hla and autoimmune diseases: type 1 diabetes (t1d) as an example
Clara Gorodezky,Carmen Alaez,Andrea Murguía,A. Rodriguez,S Balladares,Miriam Vazquez,H. Flores,Carlos Robles +7 more
TL;DR: In most populations, the absence of D-57 and the presence of R-52 are important to the susceptibility, but in Hispanics, all DR4s (including the protective DRB1*0403/*0407/*0411) are in linkage disequilibrium with DQA1/DQB1 susceptibility alleles.
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Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.
Jill A. Hollenbach,A. Meenagh,C. Sleator,Carmen Alaez,M. Bengoche,Angelica Canossi,Gabriel Contreras,Lisa E. Creary,Irina Evseeva,Clara Gorodezky,Rae-Anne Hardie,T. Hemming Karlsen,B. A. Lie,Ma Luo,Miryam Martinetti,C. Navarette,D. C. M. de Oliveira,G. Ozzella,A. Pasi,E. Pavlova,Sandro Pinto,Luís Cristóvão Porto,P. Santos,Antonij Slavcev,D. Srinak,Sofia Tavoularis,Susan Tonks,Elizabeth Trachtenberg,Sasijit Vejbaesya,Derek Middleton +29 more
TL;DR: Investigation of allele-level variation for the B haplotype locus KIR 2DL2 showed that two alleles, *001 and *003, predominate in all populations in this study.
Journal ArticleDOI
Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease.
Carmen Alaez,Maria del Pilar Mora,Lourdes Arellanes,Silvia Cano,Elva Pérez-Luque,Miriam Vazquez,A. Olivo,Ana Burguete,Arturo Hernandez,Miguel Pedroza,Clara Gorodezky +10 more
TL;DR: DNA typing of HLA-DRB1, DQA1 and DQB1 was done following the 12th International Histocompatibility protocols, suggesting that residues E-9 V-11, H-13; H-33 and Y-37 shared by all DR4s are implicated in susceptibility to VKH.