C
Carol J. Milligan
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 42
Citations - 2780
Carol J. Milligan is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Transient receptor potential channel & Receptor. The author has an hindex of 25, co-authored 40 publications receiving 2526 citations. Previous affiliations of Carol J. Milligan include University of Leeds.
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Journal ArticleDOI
Neuronal P2X7 Receptors Are Targeted to Presynaptic Terminals in the Central and Peripheral Nervous Systems
Susan A. Deuchars,Lucy Atkinson,Ruth E. Brooke,Hanny Musa,Carol J. Milligan,Trevor F.C. Batten,Noel J. Buckley,Simon H. Parson,Jim Deuchars +8 more
TL;DR: RT-PCR is used to demonstrate that transcripts for the P2X7 receptor are present in extracts from the medulla oblongata, spinal cord, and nodose ganglion, suggesting that the receptor may be involved in the fundamental regulation of synaptic transmission at the presynaptic site.
Journal ArticleDOI
TRPC channel activation by extracellular thioredoxin
Shang-Zhong Xu,Piruthivi Sukumar,Fanning Zeng,Jing Li,Amit Jairaman,Anne English,Jacqueline Naylor,Coziana Ciurtin,Yasser Majeed,Carol J. Milligan,Yahya M Bahnasi,Eman Alshawaf,Karen E. Porter,Lin-Hua Jiang,Paul Emery,Asipu Sivaprasadarao,David J. Beech +16 more
TL;DR: TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, that endogenous TRPC5–TRPC1 channels of the cells are activated by reduced thioredoxin, and that blockade of the channels enhances secretory activity and prevents the suppression of secretion by thiOREDoxin.
Journal ArticleDOI
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Beáta Sperlágh,Attila Köfalvi,Jim Deuchars,Lucy Atkinson,Carol J. Milligan,Noel J. Buckley,E. Sylvester Vizi +6 more
TL;DR: P2X7Rs are localized to the excitatory terminals in the hippocampus, and their activation regulates the release of glutamate and GABA from themselves and from their target cells.
Journal ArticleDOI
KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.
Carol J. Milligan,Melody Li,Elena V. Gazina,Sarah E. Heron,Umesh Nair,Chantel Trager,Christopher A. Reid,Anu Venkat,Donald P. Younkin,Dennis J. Dlugos,Slavé Petrovski,Slavé Petrovski,David Goldstein,Leanne M. Dibbens,Ingrid E. Scheffer,Samuel F. Berkovic,Steven Petrou +16 more
TL;DR: This work aims to investigate the electrophysiological and pharmacological characteristics of hKCNT1 mutations and examine developmental expression levels in children with epilepsy of infancy with migrating focal seizures.
Journal ArticleDOI
Quinidine in the treatment of KCNT1-positive epilepsies.
Mohamad A. Mikati,Yong-hui Jiang,Michael P. Carboni,Vandana Shashi,Slavé Petrovski,Rebecca C. Spillmann,Carol J. Milligan,Melody Li,Annette Grefe,Allyn McConkie,Samuel F. Berkovic,Ingrid E. Scheffer,Saul A. Mullen,Melanie J. Bonner,Steven Petrou,David Goldstein +15 more
TL;DR: Although quinidine represents an encouraging opportunity for therapeutic benefits, the experience suggests caution in its application and supports the need to identify more targeted drugs for KCNT1 epilepsies.