P
Piruthivi Sukumar
Researcher at University of Leeds
Publications - 53
Citations - 2273
Piruthivi Sukumar is an academic researcher from University of Leeds. The author has contributed to research in topics: Endothelium & Insulin resistance. The author has an hindex of 22, co-authored 50 publications receiving 1964 citations. Previous affiliations of Piruthivi Sukumar include Indian Institute of Technology Guwahati & Indian Institutes of Technology.
Papers
More filters
Journal ArticleDOI
TRPC channel activation by extracellular thioredoxin
Shang-Zhong Xu,Piruthivi Sukumar,Fanning Zeng,Jing Li,Amit Jairaman,Anne English,Jacqueline Naylor,Coziana Ciurtin,Yasser Majeed,Carol J. Milligan,Yahya M Bahnasi,Eman Alshawaf,Karen E. Porter,Lin-Hua Jiang,Paul Emery,Asipu Sivaprasadarao,David J. Beech +16 more
TL;DR: TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, that endogenous TRPC5–TRPC1 channels of the cells are activated by reduced thioredoxin, and that blockade of the channels enhances secretory activity and prevents the suppression of secretion by thiOREDoxin.
Journal ArticleDOI
Upregulated TRPC1 Channel in Vascular Injury In Vivo and Its Role in Human Neointimal Hyperplasia
Bhaskar Kumar,Karl Dreja,Samir S. Shah,Alex Cheong,Shang-Zhong Xu,Piruthivi Sukumar,Jacqueline Naylor,Amalia Forte,Marilena Cipollaro,Damian McHugh,Paul A Kingston,Anthony M. Heagerty,Christopher M. Munsch,Andreas Bergdahl,Anna Hultgårdh-Nilsson,Maria F. Gomez,K. E. Porter,Per Hellstrand,David J. Beech +18 more
TL;DR: The data suggest upregulated TRPC1 is a general feature of smooth muscle cells in occlusive vascular disease and that TR PC1 inhibitors have potential as protective agents against human vascular failure.
Journal ArticleDOI
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Baptiste Rode,Jian Shi,Naima Endesh,Mark J. Drinkhill,Peter J. Webster,Sabine Lotteau,Marc A. Bailey,Nadira Yuldasheva,Melanie J. Ludlow,Richard M Cubbon,Jing Li,T. Simon Futers,Lara C Morley,Hannah J. Gaunt,Katarzyna Marszalek,Hema Viswambharan,Kevin Cuthbertson,Paul D. Baxter,Richard Foster,Piruthivi Sukumar,Andrew Weightman,Sarah Calaghan,Stephen B. Wheatcroft,Mark T. Kearney,David J. Beech +24 more
TL;DR: The data suggest that Piezo1 channels sense physical activity to advantageously reset vascular control and are a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.
Journal ArticleDOI
A Sphingosine-1–Phosphate-Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility
Shang-Zhong Xu,Katsuhiko Muraki,Fanning Zeng,Jing Li,Piruthivi Sukumar,Samir S. Shah,Alexandra M. Dedman,Philippa K. Flemming,Damian McHugh,Jacqueline Naylor,Alex Cheong,Alan N. Bateson,Christopher M. Munsch,Karen E. Porter,David J. Beech +14 more
TL;DR: The data suggest S1P sensing by TRPC5 calcium channel is a mechanism contributing to vascular smooth muscle adaptation and appears to have a primary role in S 1P-evoked cell motility.
Journal ArticleDOI
Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.
Alex Cheong,Andrew J Bingham,Jing Li,Bhaskar Kumar,Piruthivi Sukumar,Christopher M. Munsch,Noel J. Buckley,Craig B. Neylon,Karen E. Porter,David J. Beech,Ian C. Wood +10 more
TL;DR: REST plays a previously unrecognized role as a switch regulating potassium channel expression and consequently the phenotype of vascular smooth muscle cells and human vascular disease.