C
Carole A. Samango-Sprouse
Researcher at George Washington University
Publications - 73
Citations - 2104
Carole A. Samango-Sprouse is an academic researcher from George Washington University. The author has contributed to research in topics: Klinefelter syndrome & Medicine. The author has an hindex of 21, co-authored 57 publications receiving 1886 citations. Previous affiliations of Carole A. Samango-Sprouse include Children's National Medical Center & Florida International University.
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Journal ArticleDOI
Puberty-related influences on brain development.
Jay N. Giedd,Liv S. Clasen,Rhoshel K. Lenroot,Dede Greenstein,Gregory L. Wallace,Sarah Ordaz,Elizabeth A. Molloy,Jonathan D. Blumenthal,Julia W. Tossell,Catherine Stayer,Carole A. Samango-Sprouse,Dinggang Shen,Christos Davatzikos,Deborah P. Merke,George P. Chrousos +14 more
TL;DR: Neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles are reviewed and synthesized to indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes.
Journal ArticleDOI
Klinefelter syndrome: Expanding the phenotype and identifying new research directions
Joe Leigh Simpson,Felix de la Cruz,Ronald S. Swerdloff,Carole A. Samango-Sprouse,Niels E. Skakkebaek,John M. Graham,Terry J. Hassold,Melissa Aylstock,Heino F. L. Meyer-Bahlburg,Huntington F. Willard,Judith G. Hall,Wael A. Salameh,Kyle B. Boone,Catherine Staessen,Daniel H. Geschwind,Jay N. Giedd,Adrian S. Dobs,Alan D. Rogol,Bonnie Brinton,C. Alvin Paulsen +19 more
TL;DR: New data on etiology and clinical features of Klinefelter syndrome is summarized in order to derive research priorities and Behavioral and expressive language difficulties are amenable to treatment by androgen therapy and psychological help.
Journal ArticleDOI
SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy
Carole A. Samango-Sprouse,Milena Banjevic,Allison Ryan,Styrmir Sigurjonsson,Bernhard Zimmermann,Matthew Hill,Megan P. Hall,Margaret Westemeyer,Jennifer Saucier,Zachary Demko,Matthew Rabinowitz +10 more
TL;DR: This study aimed to develop a single‐nucleotide polymorphism‐based and informatics‐based non‐invasive prenatal test that detects sex chromosome aneuploidies early in pregnancy.
Journal ArticleDOI
Early Androgen Deficiency in Infants and Young Boys with 47,XXY Klinefelter Syndrome
Judith L. Ross,Carole A. Samango-Sprouse,Najiba Lahlou,Karen Kowal,Karen Kowal,Frederick F.B. Elder,Andrew R. Zinn +6 more
TL;DR: The physical phenotype in infants and young boys with KS (1–23 months old) includes normal auxologic measurements and early evidence of testicular failure, and Muscle tone was decreased in most of the boys.
Journal ArticleDOI
XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control study.
Jay N. Giedd,Liv S. Clasen,Gregory L. Wallace,Rhoshel K. Lenroot,Jason P. Lerch,Elizabeth Wells,Jonathan D. Blumenthal,Jean Nelson,Julia W. Tossell,Catherine Stayer,Alan C. Evans,Carole A. Samango-Sprouse +11 more
TL;DR: The brain-imaging findings of preferentially affected frontal, temporal, and motor regions and relative sparing of parietal regions are consistent with observed cognitive and behavioral strengths and weaknesses in XXY subjects.