C
Caroline André
Researcher at University of Bordeaux
Publications - 18
Citations - 2922
Caroline André is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Proinflammatory cytokine & Inflammation. The author has an hindex of 15, co-authored 18 publications receiving 2520 citations. Previous affiliations of Caroline André include French Institute of Health and Medical Research & Institut national de la recherche agronomique.
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Journal ArticleDOI
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
Jason C. O'Connor,Marcus A. Lawson,Caroline André,Maïté M. Moreau,Jacques Lestage,Nathalie Castanon,Keith W. Kelley,Keith W. Kelley,Robert Dantzer +8 more
TL;DR: Results implicate IDO as a critical molecular mediator of inflammation-induced depressive-like behavior, probably through the catabolism of tryptophan along the kynurenine pathway.
Journal ArticleDOI
Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin
Jason C. O'Connor,Caroline André,Yun-Xia Wang,Marcus A. Lawson,Sandra S. Szegedi,Jacques Lestage,Nathalie Castanon,Keith W. Kelley,Robert Dantzer,Robert Dantzer +9 more
TL;DR: It is demonstrated that IFNγ, with TNFα, is necessary for induction of IDO and depressive-like behavior in mice after BCG infection and synergized to induce IDO in primary microglia.
Journal ArticleDOI
Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior.
Jason C. O'Connor,Marcus A. Lawson,Caroline André,Eileen M. Briley,Sandra S. Szegedi,Jacques Lestage,Nathalie Castanon,Miles Herkenham,Robert Dantzer,Keith W. Kelley +9 more
TL;DR: These results are the first to prove that the BCG-induced persistent activation of IDO is accompanied by the induction of 3-hydroxyanthranilic acid oxygenase and thatIDO is required as an initial step for the subsequent development of chronic depressive-like behavior.
Journal ArticleDOI
Cognitive and Emotional Alterations Are Related to Hippocampal Inflammation in a Mouse Model of Metabolic Syndrome
A.L. Dinel,Caroline André,Caroline André,Agnès Aubert,Agnès Aubert,Guillaume Ferreira,Guillaume Ferreira,Sophie Layé,Sophie Layé,Nathalie Castanon,Nathalie Castanon +10 more
TL;DR: Behavioral alterations of db/db mice were associated with increased inflammatory cytokines and reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus but not the hypothalamus, which strongly point to interactions between cytokine and central processes involving the hippocampus as important contributing factor to the behavioral alterations ofdb/ db mice.
Journal ArticleDOI
Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation
Caroline André,A.L. Dinel,Guillaume Ferreira,Sophie Layé,Nathalie Castanon,Nathalie Castanon +5 more
TL;DR: WD exposure alters cognition and anxiety in unstimulated conditions and enhances activation of neurobiological mechanisms underlying depression after immune stimulation, suggesting that obesity, and possibly obesity-associated inflammatory priming, may represent a vulnerability state to immune-mediated depressive symptoms.