C
Caroline E. Heidbreder
Researcher at University of Illinois at Chicago
Publications - 4
Citations - 525
Caroline E. Heidbreder is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: microRNA & Gene knockdown. The author has an hindex of 4, co-authored 4 publications receiving 497 citations.
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Journal ArticleDOI
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
Lu Jiang,Xiqiang Liu,Zujian Chen,Yi Jin,Caroline E. Heidbreder,Antonia Kolokythas,Anxun Wang,Anxun Wang,Yang Dai,Xiaofeng Zhou +9 more
TL;DR: The present results demonstrated that miR-7 regulates the IGF1R/Akt signalling pathway by post-transcriptional regulation of IGF2R and may serve as a novel therapeutic target for TSCC patients.
Journal ArticleDOI
Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Lu Jiang,Xiqiang Liu,Xiqiang Liu,Antonia Kolokythas,Jinsheng Yu,Anxun Wang,Anxun Wang,Caroline E. Heidbreder,Fei Shi,Xiaofeng Zhou +9 more
TL;DR: The results suggest that miR‐138 plays an important role in TSCC cell migration and invasion by concurrently targeting RhoC and ROCK2, and miR-138 may serve as a novel therapeutic target for TSCC patients at risk of metastatic disease.
Journal ArticleDOI
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
Xiqiang Liu,Anxun Wang,Anxun Wang,Caroline E. Heidbreder,Lu Jiang,Jinsheng Yu,Antonia Kolokythas,Lei Huang,Yang Dai,Xiaofeng Zhou +9 more
TL;DR: The up‐regulation of miR‐24 in TSCC reduced the expression of RNA‐binding protein dead end 1 (DND1) and suppression of cyclin‐dependent kinase inhibitor 1B (CDKN1B) and led to enhanced proliferation and reduced apoptosis in TS CC cells.
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Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
Lu Jiang,Yang Dai,Xiqiang Liu,Cheng Wang,Anxun Wang,Anxun Wang,Zujian Chen,Caroline E. Heidbreder,Antonia Kolokythas,Xiaofeng Zhou +9 more
TL;DR: A number of high-confident miR-138 target genes are identified, including proto-oncogene GNAI2, which may play an important role in TSCC initiation and progression.